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Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic acid (MK-0533): a novel selective peroxisome proliferator-activated receptor gamma modulator for the treatment of type 2 diabetes mellitus with a reduced potential to increase plasma and extracellular fluid volume.
J Med Chem. 2009 Jul 9;52(13):3846-54. doi: 10.1021/jm900097m.
J Med Chem. 2009.
PMID: 19507861
Selective PPARgamma modulators with improved pharmacological profiles.
Liu K, Black RM, Acton JJ 3rd, Mosley R, Debenham S, Abola R, Yang M, Tschirret-Guth R, Colwell L, Liu C, Wu M, Wang CF, MacNaul KL, McCann ME, Moller DE, Berger JP, Meinke PT, Jones AB, Wood HB.
Liu K, et al. Among authors: acton jj 3rd.
Bioorg Med Chem Lett. 2005 May 16;15(10):2437-40. doi: 10.1016/j.bmcl.2005.03.092.
Bioorg Med Chem Lett. 2005.
PMID: 15863293
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Benzoyl 2-methyl indoles as selective PPARgamma modulators.
Acton JJ 3rd, Black RM, Jones AB, Moller DE, Colwell L, Doebber TW, Macnaul KL, Berger J, Wood HB.
Acton JJ 3rd, et al.
Bioorg Med Chem Lett. 2005 Jan 17;15(2):357-62. doi: 10.1016/j.bmcl.2004.10.068.
Bioorg Med Chem Lett. 2005.
PMID: 15603954
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Tetrapeptide derived inhibitors of complexation of a class II MHC: fully unnatural ligands.
Jones AB, Acton JJ 3rd, Adams AD, Yuen W, Nichols EA, Schwartz CD, Wicker LS, Hermes JD.
Jones AB, et al. Among authors: acton jj 3rd.
Bioorg Med Chem Lett. 1999 Jul 19;9(14):2115-8.
Bioorg Med Chem Lett. 1999.
PMID: 10450992
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Tetrapeptide derived inhibitors of complexation of a class II MHC: the peptide backbone is not inviolate.
Jones AB, Acton JJ 3rd, Rivetna MN, Cummings RT, Cubbon RM, Nichols EA, Schwartz CD, Wicker LS, Hermes JD.
Jones AB, et al. Among authors: acton jj 3rd.
Bioorg Med Chem Lett. 1999 Jul 19;9(14):2109-14. doi: 10.1016/s0960-894x(99)00333-9.
Bioorg Med Chem Lett. 1999.
PMID: 10450991
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