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Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene.
Ertekin-Taner N, Ronald J, Feuk L, Prince J, Tucker M, Younkin L, Hella M, Jain S, Hackett A, Scanlin L, Kelly J, Kihiko-Ehman M, Neltner M, Hersh L, Kindy M, Markesbery W, Hutton M, de Andrade M, Petersen RC, Graff-Radford N, Estus S, Brookes AJ, Younkin SG. Ertekin-Taner N, et al. Among authors: kindy m. Hum Mol Genet. 2005 Feb 1;14(3):447-60. doi: 10.1093/hmg/ddi041. Epub 2004 Dec 22. Hum Mol Genet. 2005. PMID: 15615772
Abeta deposition is essential to AD neuropathology.
Estus S, Borchelt D, Kindy MS, Vassar R. Estus S, et al. J Alzheimers Dis. 2002 Jun;4(3):133-8. doi: 10.3233/jad-2002-4302. J Alzheimers Dis. 2002. PMID: 12226531 No abstract available.
Neprilysin regulates amyloid Beta peptide levels.
Marr RA, Guan H, Rockenstein E, Kindy M, Gage FH, Verma I, Masliah E, Hersh LB. Marr RA, et al. Among authors: kindy m. J Mol Neurosci. 2004;22(1-2):5-11. doi: 10.1385/JMN:22:1-2:5. J Mol Neurosci. 2004. PMID: 14742905
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