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Challenges in the conduct of large simple trials of important generic questions in resource-poor settings: the CREATE and ECLA trial program evaluating GIK (glucose, insulin and potassium) and low-molecular-weight heparin in acute myocardial infarction.
Yusuf S, Mehta SR, Díaz R, Paolasso E, Pais P, Xavier D, Xie C, Ahmed RJ, Khazmi K, Zhu J, Liu L; CREATE-ECLA investigators and steering committee. Yusuf S, et al. Among authors: liu l. Am Heart J. 2004 Dec;148(6):1068-78. doi: 10.1016/j.ahj.2004.08.033. Am Heart J. 2004. PMID: 15632895 Free PMC article.
Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: the CREATE-ECLA randomized controlled trial.
Mehta SR, Yusuf S, Díaz R, Zhu J, Pais P, Xavier D, Paolasso E, Ahmed R, Xie C, Kazmi K, Tai J, Orlandini A, Pogue J, Liu L; CREATE-ECLA Trial Group Investigators. Mehta SR, et al. Among authors: liu l. JAMA. 2005 Jan 26;293(4):437-46. doi: 10.1001/jama.293.4.437. JAMA. 2005. PMID: 15671428 Clinical Trial.
Oral anticoagulant and antiplatelet therapy and peripheral arterial disease.
Warfarin Antiplatelet Vascular Evaluation Trial Investigators; Anand S, Yusuf S, Xie C, Pogue J, Eikelboom J, Budaj A, Sussex B, Liu L, Guzman R, Cina C, Crowell R, Keltai M, Gosselin G. Warfarin Antiplatelet Vascular Evaluation Trial Investigators, et al. Among authors: liu l. N Engl J Med. 2007 Jul 19;357(3):217-27. doi: 10.1056/NEJMoa065959. N Engl J Med. 2007. PMID: 17634457 Free article. Clinical Trial.
Telmisartan, ramipril, or both in patients at high risk for vascular events.
ONTARGET Investigators; Yusuf S, Teo KK, Pogue J, Dyal L, Copland I, Schumacher H, Dagenais G, Sleight P, Anderson C. ONTARGET Investigators, et al. N Engl J Med. 2008 Apr 10;358(15):1547-59. doi: 10.1056/NEJMoa0801317. Epub 2008 Mar 31. N Engl J Med. 2008. PMID: 18378520 Free article. Clinical Trial.
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