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Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus.
Smyth D, Cooper JD, Collins JE, Heward JM, Franklyn JA, Howson JM, Vella A, Nutland S, Rance HE, Maier L, Barratt BJ, Guja C, Ionescu-Tîrgoviste C, Savage DA, Dunger DB, Widmer B, Strachan DP, Ring SM, Walker N, Clayton DG, Twells RC, Gough SC, Todd JA. Smyth D, et al. Among authors: clayton dg. Diabetes. 2004 Nov;53(11):3020-3. doi: 10.2337/diabetes.53.11.3020. Diabetes. 2004. PMID: 15504986
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V, Bailey R, Nejentsev S, Field SF, Payne F, Lowe CE, Szeszko JS, Hafler JP, Zeitels L, Yang JH, Vella A, Nutland S, Stevens HE, Schuilenburg H, Coleman G, Maisuria M, Meadows W, Smink LJ, Healy B, Burren OS, Lam AA, Ovington NR, Allen J, Adlem E, Leung HT, Wallace C, Howson JM, Guja C, Ionescu-Tîrgovişte C; Genetics of Type 1 Diabetes in Finland; Simmonds MJ, Heward JM, Gough SC; Wellcome Trust Case Control Consortium; Dunger DB, Wicker LS, Clayton DG. Todd JA, et al. Among authors: clayton dg. Nat Genet. 2007 Jul;39(7):857-64. doi: 10.1038/ng2068. Epub 2007 Jun 6. Nat Genet. 2007. PMID: 17554260 Free PMC article.
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A.
Nejentsev S, Howson JM, Walker NM, Szeszko J, Field SF, Stevens HE, Reynolds P, Hardy M, King E, Masters J, Hulme J, Maier LM, Smyth D, Bailey R, Cooper JD, Ribas G, Campbell RD, Clayton DG, Todd JA; Wellcome Trust Case Control Consortium. Nejentsev S, et al. Among authors: clayton dg. Nature. 2007 Dec 6;450(7171):887-92. doi: 10.1038/nature06406. Epub 2007 Nov 14. Nature. 2007. PMID: 18004301 Free PMC article.
Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility.
Barton A, Thomson W, Ke X, Eyre S, Hinks A, Bowes J, Gibbons L, Plant D; Wellcome Trust Case Control Consortium; Wilson AG, Marinou I, Morgan A, Emery P; YEAR consortium; Steer S, Hocking L, Reid DM, Wordsworth P, Harrison P, Worthington J. Barton A, et al. Hum Mol Genet. 2008 Aug 1;17(15):2274-9. doi: 10.1093/hmg/ddn128. Epub 2008 Apr 22. Hum Mol Genet. 2008. PMID: 18434327 Free PMC article.
121 results