Sardana M - Search Results

1

Compounds that bind APP and inhibit Abeta processing in vitro suggest a novel approach to Alzheimer disease therapeutics.

Espeseth AS, Xu M, Huang Q, Coburn CA, Jones KL, Ferrer M, Zuck PD, Strulovici B, Price EA, Wu G, Wolfe AL, Lineberger JE, Sardana M, Tugusheva K, Pietrak BL, Crouthamel MC, Lai MT, Dodson EC, Bazzo R, Shi XP, Simon AJ, Li Y, Hazuda DJ. Espeseth AS, et al. Among authors: sardana m. J Biol Chem. 2005 May 6;280(18):17792-7. doi: 10.1074/jbc.M414331200. Epub 2005 Feb 25. J Biol Chem. 2005. PMID: 15737955 Free article.

2

Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity.

Shi XP, Tugusheva K, Bruce JE, Lucka A, Wu GX, Chen-Dodson E, Price E, Li Y, Xu M, Huang Q, Sardana MK, Hazuda DJ. Shi XP, et al. Among authors: sardana mk. J Biol Chem. 2003 Jun 6;278(23):21286-94. doi: 10.1074/jbc.M209859200. Epub 2003 Mar 27. J Biol Chem. 2003. PMID: 12665519 Free article.

3

Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells.

Shi XP, Tugusheva K, Bruce JE, Lucka A, Chen-Dodson E, Hu B, Wu GX, Price E, Register RB, Lineberger J, Miller R, Tang MJ, Espeseth A, Kahana J, Wolfe A, Crouthamel MC, Sankaranarayanan S, Simon A, Chen L, Lai MT, Pietrak B, DiMuzio J, Li Y, Xu M, Huang Q, Garsky V, Sardana MK, Hazuda DJ. Shi XP, et al. Among authors: sardana mk. J Alzheimers Dis. 2005 Apr;7(2):139-48; discussion 173-80. doi: 10.3233/jad-2005-7207. J Alzheimers Dis. 2005. PMID: 15851852

4

The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain.

Shi XP, Chen E, Yin KC, Na S, Garsky VM, Lai MT, Li YM, Platchek M, Register RB, Sardana MK, Tang MJ, Thiebeau J, Wood T, Shafer JA, Gardell SJ. Shi XP, et al. Among authors: sardana mk. J Biol Chem. 2001 Mar 30;276(13):10366-73. doi: 10.1074/jbc.m009200200. J Biol Chem. 2001. PMID: 11266439 Free article.

5

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state.

Li YM, Lai MT, Xu M, Huang Q, DiMuzio-Mower J, Sardana MK, Shi XP, Yin KC, Shafer JA, Gardell SJ. Li YM, et al. Among authors: sardana mk. Proc Natl Acad Sci U S A. 2000 May 23;97(11):6138-43. doi: 10.1073/pnas.110126897. Proc Natl Acad Sci U S A. 2000. PMID: 10801983 Free PMC article.

6

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.

Li YM, Xu M, Lai MT, Huang Q, Castro JL, DiMuzio-Mower J, Harrison T, Lellis C, Nadin A, Neduvelil JG, Register RB, Sardana MK, Shearman MS, Smith AL, Shi XP, Yin KC, Shafer JA, Gardell SJ. Li YM, et al. Among authors: sardana mk. Nature. 2000 Jun 8;405(6787):689-94. doi: 10.1038/35015085. Nature. 2000. PMID: 10864326

7

Purification, solution properties and crystallization of SIV integrase containing a continuous core and C-terminal domain.

Li Y, Yan Y, Zugay-Murphy J, Xu B, Cole JL, Witmer M, Felock P, Wolfe A, Hazuda D, Sardana MK, Chen Z, Kuo LC, Sardana VV. Li Y, et al. Among authors: sardana mk, sardana vv. Acta Crystallogr D Biol Crystallogr. 1999 Nov;55(Pt 11):1906-10. doi: 10.1107/s0907444999009610. Acta Crystallogr D Biol Crystallogr. 1999. PMID: 10531491

8

Purification of active herpes simplex virus-1 protease expressed in Escherichia coli.

Darke PL, Chen E, Hall DL, Sardana MK, Veloski CA, LaFemina RL, Shafer JA, Kuo LC. Darke PL, et al. Among authors: sardana mk. J Biol Chem. 1994 Jul 22;269(29):18708-11. J Biol Chem. 1994. PMID: 8034621 Free article.

9

Selective inhibition of factor Xa in the prothrombinase complex by the carboxyl-terminal domain of antistasin.

Mao SS, Przysiecki CT, Krueger JA, Cooper CM, Lewis SD, Joyce J, Lellis C, Garsky VM, Sardana M, Shafer JA. Mao SS, et al. Among authors: sardana m. J Biol Chem. 1998 Nov 13;273(46):30086-91. doi: 10.1074/jbc.273.46.30086. J Biol Chem. 1998. PMID: 9804761 Free article.

10

A general procedure for the purification of human beta-secretase expressed in Escherichia coli.

Sardana V, Xu B, Zugay-Murphy J, Chen Z, Sardana M, Darke PL, Munshi S, Kuo LC. Sardana V, et al. Among authors: sardana m. Protein Expr Purif. 2004 Apr;34(2):190-6. doi: 10.1016/j.pep.2003.12.014. Protein Expr Purif. 2004. PMID: 15003250

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