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Compounds that bind APP and inhibit Abeta processing in vitro suggest a novel approach to Alzheimer disease therapeutics.
Espeseth AS, Xu M, Huang Q, Coburn CA, Jones KL, Ferrer M, Zuck PD, Strulovici B, Price EA, Wu G, Wolfe AL, Lineberger JE, Sardana M, Tugusheva K, Pietrak BL, Crouthamel MC, Lai MT, Dodson EC, Bazzo R, Shi XP, Simon AJ, Li Y, Hazuda DJ. Espeseth AS, et al. Among authors: strulovici b. J Biol Chem. 2005 May 6;280(18):17792-7. doi: 10.1074/jbc.M414331200. Epub 2005 Feb 25. J Biol Chem. 2005. PMID: 15737955 Free article.
LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease.
Majercak J, Ray WJ, Espeseth A, Simon A, Shi XP, Wolffe C, Getty K, Marine S, Stec E, Ferrer M, Strulovici B, Bartz S, Gates A, Xu M, Huang Q, Ma L, Shughrue P, Burchard J, Colussi D, Pietrak B, Kahana J, Beher D, Rosahl T, Shearman M, Hazuda D, Sachs AB, Koblan KS, Seabrook GR, Stone DJ. Majercak J, et al. Among authors: strulovici b. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17967-72. doi: 10.1073/pnas.0605461103. Epub 2006 Nov 10. Proc Natl Acad Sci U S A. 2006. PMID: 17098871 Free PMC article.
Genome-scale RNAi screen for host factors required for HIV replication.
Zhou H, Xu M, Huang Q, Gates AT, Zhang XD, Castle JC, Stec E, Ferrer M, Strulovici B, Hazuda DJ, Espeseth AS. Zhou H, et al. Among authors: strulovici b. Cell Host Microbe. 2008 Nov 13;4(5):495-504. doi: 10.1016/j.chom.2008.10.004. Epub 2008 Oct 30. Cell Host Microbe. 2008. PMID: 18976975 Free article.
Hit selection with false discovery rate control in genome-scale RNAi screens.
Zhang XD, Kuan PF, Ferrer M, Shu X, Liu YC, Gates AT, Kunapuli P, Stec EM, Xu M, Marine SD, Holder DJ, Strulovici B, Heyse JF, Espeseth AS. Zhang XD, et al. Among authors: strulovici b. Nucleic Acids Res. 2008 Aug;36(14):4667-79. doi: 10.1093/nar/gkn435. Epub 2008 Jul 15. Nucleic Acids Res. 2008. PMID: 18628291 Free PMC article.
76 results