Mototani H - Search Results

1

A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese.

Mototani H, Mabuchi A, Saito S, Fujioka M, Iida A, Takatori Y, Kotani A, Kubo T, Nakamura K, Sekine A, Murakami Y, Tsunoda T, Notoya K, Nakamura Y, Ikegawa S. Mototani H, et al. Hum Mol Genet. 2005 Apr 15;14(8):1009-17. doi: 10.1093/hmg/ddi093. Epub 2005 Mar 3. Hum Mol Genet. 2005. PMID: 15746150

2

A functional SNP in EDG2 increases susceptibility to knee osteoarthritis in Japanese.

Mototani H, Iida A, Nakajima M, Furuichi T, Miyamoto Y, Tsunoda T, Sudo A, Kotani A, Uchida A, Ozaki K, Tanaka Y, Nakamura Y, Tanaka T, Notoya K, Ikegawa S. Mototani H, et al. Hum Mol Genet. 2008 Jun 15;17(12):1790-7. doi: 10.1093/hmg/ddn069. Epub 2008 Mar 6. Hum Mol Genet. 2008. PMID: 18325907

3

Identification of sequence polymorphisms in CALM2 and analysis of association with hip osteoarthritis in a Japanese population.

Mototani H, Iida A, Nakamura Y, Ikegawa S. Mototani H, et al. J Bone Miner Metab. 2010 Sep;28(5):547-53. doi: 10.1007/s00774-010-0161-8. Epub 2010 Mar 3. J Bone Miner Metab. 2010. PMID: 20198394

4

Multi-dimensional analysis identified rheumatoid arthritis-driving pathway in human T cell.

Takeshita M, Suzuki K, Kondo Y, Morita R, Okuzono Y, Koga K, Kassai Y, Gamo K, Takiguchi M, Kurisu R, Mototani H, Ebisuno Y, Yoshimura A, Takeuchi T. Takeshita M, et al. Among authors: mototani h. Ann Rheum Dis. 2019 Oct;78(10):1346-1356. doi: 10.1136/annrheumdis-2018-214885. Epub 2019 Jun 5. Ann Rheum Dis. 2019. PMID: 31167762 Free PMC article.

5

Discovery of novel, highly potent, and selective quinazoline-2-carboxamide-based matrix metalloproteinase (MMP)-13 inhibitors without a zinc binding group using a structure-based design approach.

Nara H, Sato K, Naito T, Mototani H, Oki H, Yamamoto Y, Kuno H, Santou T, Kanzaki N, Terauchi J, Uchikawa O, Kori M. Nara H, et al. Among authors: mototani h. J Med Chem. 2014 Nov 13;57(21):8886-902. doi: 10.1021/jm500981k. Epub 2014 Oct 15. J Med Chem. 2014. PMID: 25264600

6

Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1″ binding site.

Nara H, Sato K, Naito T, Mototani H, Oki H, Yamamoto Y, Kuno H, Santou T, Kanzaki N, Terauchi J, Uchikawa O, Kori M. Nara H, et al. Among authors: mototani h. Bioorg Med Chem. 2014 Oct 1;22(19):5487-505. doi: 10.1016/j.bmc.2014.07.025. Epub 2014 Aug 7. Bioorg Med Chem. 2014. PMID: 25192810

7

Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach.

Nara H, Kaieda A, Sato K, Naito T, Mototani H, Oki H, Yamamoto Y, Kuno H, Santou T, Kanzaki N, Terauchi J, Uchikawa O, Kori M. Nara H, et al. Among authors: mototani h. J Med Chem. 2017 Jan 26;60(2):608-626. doi: 10.1021/acs.jmedchem.6b01007. Epub 2017 Jan 9. J Med Chem. 2017. PMID: 27966948

8

Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1H)-ones as potent and selective PKCθ inhibitors.

Katoh T, Takai T, Yukawa T, Tsukamoto T, Watanabe E, Mototani H, Arita T, Hayashi H, Nakagawa H, Klein MG, Zou H, Sang BC, Snell G, Nakada Y. Katoh T, et al. Among authors: mototani h. Bioorg Med Chem. 2016 Jun 1;24(11):2466-2475. doi: 10.1016/j.bmc.2016.04.008. Epub 2016 Apr 4. Bioorg Med Chem. 2016. PMID: 27117263

9

Raman spectroscopic study on the copper(II) binding mode of prion octapeptide and its pH dependence.

Miura T, Hori-i A, Mototani H, Takeuchi H. Miura T, et al. Among authors: mototani h. Biochemistry. 1999 Aug 31;38(35):11560-9. doi: 10.1021/bi9909389. Biochemistry. 1999. PMID: 10471308

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