Lipton LR - Search Results

1

Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC and for the existence of distinct groups of non-HNPCC families.

Johnson V, Lipton LR, Cummings C, Eftekhar Sadat AT, Izatt L, Hodgson SV, Talbot IC, Thomas HJ, Silver AJ, Tomlinson IP. Johnson V, et al. Among authors: lipton lr. J Med Genet. 2005 Oct;42(10):756-62. doi: 10.1136/jmg.2005.031245. Epub 2005 Mar 23. J Med Genet. 2005. PMID: 15788729 Free PMC article.

2

Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas.

Sieber OM, Lamlum H, Crabtree MD, Rowan AJ, Barclay E, Lipton L, Hodgson S, Thomas HJ, Neale K, Phillips RK, Farrington SM, Dunlop MG, Mueller HJ, Bisgaard ML, Bulow S, Fidalgo P, Albuquerque C, Scarano MI, Bodmer W, Tomlinson IP, Heinimann K. Sieber OM, et al. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2954-8. doi: 10.1073/pnas.042699199. Epub 2002 Feb 26. Proc Natl Acad Sci U S A. 2002. PMID: 11867715 Free PMC article.

3

Colorectal tumourigenesis in carriers of the APC I1307K variant: lone gunman or conspiracy?

Sieber O, Lipton L, Heinimann K, Tomlinson I. Sieber O, et al. J Pathol. 2003 Feb;199(2):137-9. doi: 10.1002/path.1272. J Pathol. 2003. PMID: 12533824 Review.

4

Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH.

Sieber OM, Lipton L, Crabtree M, Heinimann K, Fidalgo P, Phillips RK, Bisgaard ML, Orntoft TF, Aaltonen LA, Hodgson SV, Thomas HJ, Tomlinson IP. Sieber OM, et al. N Engl J Med. 2003 Feb 27;348(9):791-9. doi: 10.1056/NEJMoa025283. N Engl J Med. 2003. PMID: 12606733 Free article.

5

Germline mutations in the TGF-beta and Wnt signalling pathways are a rare cause of the "multiple" adenoma phenotype.

Lipton L, Sieber OM, Thomas HJ, Hodgson SV, Tomlinson IP, Woodford-Richens K. Lipton L, et al. J Med Genet. 2003 Apr;40(4):e35. doi: 10.1136/jmg.40.4.e35. J Med Genet. 2003. PMID: 12676908 Free PMC article. No abstract available.

6

Genome-wide allelotyping of 104 Finnish colorectal cancers reveals an excess of allelic imbalance in chromosome 20q in familial cases.

Laiho P, Hienonen T, Karhu A, Lipton L, Aalto Y, Thomas HJ, Birkenkamp-Demtroder K, Hodgson S, Salovaara R, Mecklin JP, Järvinen H, Knuutila S, Halford S, Ørntoft TF, Tomlinson I, Launonen V, Houlston R, Aaltonen LA. Laiho P, et al. Oncogene. 2003 Apr 10;22(14):2206-14. doi: 10.1038/sj.onc.1206294. Oncogene. 2003. PMID: 12687022

7

Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers.

Halford SE, Rowan AJ, Lipton L, Sieber OM, Pack K, Thomas HJ, Hodgson SV, Bodmer WF, Tomlinson IP. Halford SE, et al. Am J Pathol. 2003 May;162(5):1545-8. doi: 10.1016/S0002-9440(10)64288-5. Am J Pathol. 2003. PMID: 12707038 Free PMC article.

8

Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients.

Crabtree M, Sieber OM, Lipton L, Hodgson SV, Lamlum H, Thomas HJ, Neale K, Phillips RK, Heinimann K, Tomlinson IP. Crabtree M, et al. Oncogene. 2003 Jul 3;22(27):4257-65. doi: 10.1038/sj.onc.1206471. Oncogene. 2003. PMID: 12833148

9

Proportion and phenotype of MYH-associated colorectal neoplasia in a population-based series of Finnish colorectal cancer patients.

Enholm S, Hienonen T, Suomalainen A, Lipton L, Tomlinson I, Kärjä V, Eskelinen M, Mecklin JP, Karhu A, Järvinen HJ, Aaltonen LA. Enholm S, et al. Am J Pathol. 2003 Sep;163(3):827-32. doi: 10.1016/S0002-9440(10)63443-8. Am J Pathol. 2003. PMID: 12937124 Free PMC article.

10

Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma.

Lipton L, Fleischmann C, Sieber OM, Thomas HJ, Hodgson SV, Tomlinson IP, Houlston RS. Lipton L, et al. Cancer Lett. 2003 Oct 28;200(2):149-52. doi: 10.1016/s0304-3835(03)00391-4. Cancer Lett. 2003. PMID: 14568168

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