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Page 1
Phenylacetic acid derivatives as hPPAR agonists.
Santini C, Berger GD, Han W, Mosley R, MacNaul K, Berger J, Doebber T, Wu M, Moller DE, Tolman RL, Sahoo SP. Santini C, et al. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1277-80. doi: 10.1016/s0960-894x(03)00115-x. Bioorg Med Chem Lett. 2003. PMID: 12657263
Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic acid (MK-0533): a novel selective peroxisome proliferator-activated receptor gamma modulator for the treatment of type 2 diabetes mellitus with a reduced potential to increase plasma and extracellular fluid volume.
Acton JJ 3rd, Akiyama TE, Chang CH, Colwell L, Debenham S, Doebber T, Einstein M, Liu K, McCann ME, Moller DE, Muise ES, Tan Y, Thompson JR, Wong KK, Wu M, Xu L, Meinke PT, Berger JP, Wood HB. Acton JJ 3rd, et al. J Med Chem. 2009 Jul 9;52(13):3846-54. doi: 10.1021/jm900097m. J Med Chem. 2009. PMID: 19507861
Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator.
Berger JP, Petro AE, Macnaul KL, Kelly LJ, Zhang BB, Richards K, Elbrecht A, Johnson BA, Zhou G, Doebber TW, Biswas C, Parikh M, Sharma N, Tanen MR, Thompson GM, Ventre J, Adams AD, Mosley R, Surwit RS, Moller DE. Berger JP, et al. Among authors: doebber tw. Mol Endocrinol. 2003 Apr;17(4):662-76. doi: 10.1210/me.2002-0217. Epub 2003 Jan 16. Mol Endocrinol. 2003. PMID: 12554792
5-Aryl thiazolidine-2,4-diones as selective PPARgamma agonists.
Koyama H, Boueres JK, Han W, Metzger EJ, Bergman JP, Gratale DF, Miller DJ, Tolman RL, MacNaul KL, Berger JP, Doebber TW, Leung K, Moller DE, Heck JV, Sahoo SP. Koyama H, et al. Among authors: doebber tw. Bioorg Med Chem Lett. 2003 May 19;13(10):1801-4. doi: 10.1016/s0960-894x(03)00257-9. Bioorg Med Chem Lett. 2003. PMID: 12729668
O-arylmandelic acids as highly selective human PPAR alpha/gamma agonists.
Adams AD, Hu Z, von Langen D, Dadiz A, Elbrecht A, MacNaul KL, Berger JP, Zhou G, Doebber TW, Meurer R, Forrest MJ, Moller DE, Jones AB. Adams AD, et al. Among authors: doebber tw. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3185-90. doi: 10.1016/s0960-894x(03)00702-9. Bioorg Med Chem Lett. 2003. PMID: 12951090
58 results