Tan L - Search Results

1

Practical asymmetric synthesis of a potent PDE4 inhibitor via stereoselective enolate alkylation of a chiral aryl-heteroaryl secondary tosylate.

O'Shea PD, Chen CY, Chen W, Dagneau P, Frey LF, Grabowski EJ, Marcantonio KM, Reamer RA, Tan L, Tillyer RD, Roy A, Wang X, Zhao D. O'Shea PD, et al. Among authors: tan l. J Org Chem. 2005 Apr 15;70(8):3021-30. doi: 10.1021/jo048156v. J Org Chem. 2005. PMID: 15822960

2

Stereoselective syntheses of highly functionalized bicyclo[3.1.0]hexanes: a general methodology for the synthesis of potent and selective mGluR2/3 agonists.

Tan L, Yasuda N, Yoshikawa N, Hartner FW, Eng KK, Leonard WR, Tsay FR, Volante RP, Tillyer RD. Tan L, et al. J Org Chem. 2005 Sep 30;70(20):8027-34. doi: 10.1021/jo0511187. J Org Chem. 2005. PMID: 16277324

3

Practical asymmetric synthesis of a selective endothelin A receptor (ETA) antagonist.

Song ZJ, Zhao M, Frey L, Li J, Tan L, Chen CY, Tschaen DM, Tillyer R, Grabowski EJ, Volante R, Reider PJ, Kato Y, Okada S, Nemoto T, Sato H, Akao A, Mase T. Song ZJ, et al. Among authors: tan l. Org Lett. 2001 Oct 18;3(21):3357-60. doi: 10.1021/ol016601s. Org Lett. 2001. PMID: 11594833

4

Promotion of a Ti-Mediated Mannich Reaction by a Proton Source.

Limanto J, Yoshikawa N, Reamer RA, Tan L, Brunskill A, Reibarkh M. Limanto J, et al. Among authors: tan l. J Org Chem. 2016 Jan 15;81(2):723-8. doi: 10.1021/acs.joc.5b02452. Epub 2015 Dec 21. J Org Chem. 2016. PMID: 26656787

5

Asymmetric Formal Synthesis of the Long-Acting DPP-4 Inhibitor Omarigliptin.

Peng F, Chen Y, Chen CY, Dormer PG, Kassim A, McLaughlin M, Reamer RA, Sherer EC, Song ZJ, Tan L, Tudge MT, Wan B, Chung JYL. Peng F, et al. Among authors: tan l. J Org Chem. 2017 Sep 1;82(17):9023-9029. doi: 10.1021/acs.joc.7b01467. Epub 2017 Aug 14. J Org Chem. 2017. PMID: 28776371 Free PMC article.

6

Chemical process evolution of efavirenz, a potent non-nucleosidal HIV reverse transcriptase inhibitor.

Chen CY, Tan L. Chen CY, et al. Among authors: tan l. Enantiomer. 1999;4(6):599-608. Enantiomer. 1999. PMID: 10672461 No abstract available.

7

A Novel, Highly Enantioselective Ketone Alkynylation Reaction Mediated by Chiral Zinc Aminoalkoxides.

Tan L, Chen CY, Tillyer RD, Grabowski EJJ, Reider PJ. Tan L, et al. Angew Chem Int Ed Engl. 1999 Mar 1;38(5):711-713. doi: 10.1002/(SICI)1521-3773(19990301)38:5<711::AID-ANIE711>3.0.CO;2-W. Angew Chem Int Ed Engl. 1999. PMID: 29711532

8

Enantioselective Synthesis of 4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) via Enzymatic Desymmetrization.

McLaughlin M, Kong J, Belyk KM, Chen B, Gibson AW, Keen SP, Lieberman DR, Milczek EM, Moore JC, Murray D, Peng F, Qi J, Reamer RA, Song ZJ, Tan L, Wang L, Williams MJ. McLaughlin M, et al. Among authors: tan l. Org Lett. 2017 Feb 17;19(4):926-929. doi: 10.1021/acs.orglett.7b00091. Epub 2017 Feb 6. Org Lett. 2017. PMID: 28165251

9

Synthesis of bis-macrocyclic HCV protease inhibitor MK-6325 via intramolecular sp²-sp³ Suzuki-Miyaura coupling and ring closing metathesis.

Li H, Scott JP, Chen CY, Journet M, Belyk K, Balsells J, Kosjek B, Baxter CA, Stewart GW, Wise C, Alam M, Song ZJ, Tan L. Li H, et al. Among authors: tan l. Org Lett. 2015 Mar 20;17(6):1533-6. doi: 10.1021/acs.orglett.5b00418. Epub 2015 Mar 10. Org Lett. 2015. PMID: 25754231

10

Highly Diastereoselective Synthesis of a HCV NS5B Nucleoside Polymerase Inhibitor.

Zhong YL, Cleator E, Liu Z, Yin J, Morris WJ, Alam M, Bishop B, Dumas AM, Edwards J, Goodyear A, Mullens P, Song ZJ, Shevlin M, Thaisrivongs DA, Li H, Sherer EC, Cohen RD, Yin J, Tan L, Yasuda N, Limanto J, Davies A, Campos KR. Zhong YL, et al. Among authors: tan l. J Org Chem. 2019 Apr 19;84(8):4780-4795. doi: 10.1021/acs.joc.8b02500. Epub 2018 Dec 10. J Org Chem. 2019. PMID: 30475616

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