Sisco RM - Search Results

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Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole.

Ashton WT, Sisco RM, Dong H, Lyons KA, He H, Doss GA, Leiting B, Patel RA, Wu JK, Marsilio F, Thornberry NA, Weber AE. Ashton WT, et al. Among authors: sisco rm. Bioorg Med Chem Lett. 2005 May 2;15(9):2253-8. doi: 10.1016/j.bmcl.2005.03.012. Bioorg Med Chem Lett. 2005. PMID: 15837304

Diastereoselective synthesis and configuration-dependent activity of (3-substituted-cycloalkyl)glycine pyrrolidides and thiazolidides as dipeptidyl peptidase IV inhibitors.

Ashton WT, Dong H, Sisco RM, Doss GA, Leiting B, Patel RA, Wu JK, Marsilio F, Thornberry NA, Weber AE. Ashton WT, et al. Among authors: sisco rm. Bioorg Med Chem Lett. 2004 Feb 23;14(4):859-63. doi: 10.1016/j.bmcl.2003.12.013. Bioorg Med Chem Lett. 2004. PMID: 15012982

Orally bioavailable, indole-based nonpeptide GnRH receptor antagonists with high potency and functional activity.

Ashton WT, Sisco RM, Kieczykowski GR, Yang YT, Yudkovitz JB, Cui J, Mount GR, Ren RN, Wu TJ, Shen X, Lyons KA, Mao AH, Carlin JR, Karanam BV, Vincent SH, Cheng K, Goulet MT. Ashton WT, et al. Among authors: sisco rm. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2597-602. doi: 10.1016/s0960-894x(01)00512-1. Bioorg Med Chem Lett. 2001. PMID: 11551758

Substituted indole-5-carboxamides and -acetamides as potent nonpeptide GnRH receptor antagonists.

Ashton WT, Sisco RM, Yang YT, Lo JL, Yudkovitz JB, Cheng K, Goulet MT. Ashton WT, et al. Among authors: sisco rm. Bioorg Med Chem Lett. 2001 Jul 9;11(13):1723-6. doi: 10.1016/s0960-894x(01)00274-8. Bioorg Med Chem Lett. 2001. PMID: 11425546

Potent nonpeptide GnRH receptor antagonists derived from substituted indole-5-carboxamides and -acetamides bearing a pyridine side-chain terminus.

Ashton WT, Sisco RM, Yang YT, Lo JL, Yudkovitz JB, Gibbons PH, Mount GR, Ren RN, Butler BS, Cheng K, Goulet MT. Ashton WT, et al. Among authors: sisco rm. Bioorg Med Chem Lett. 2001 Jul 9;11(13):1727-31. doi: 10.1016/s0960-894x(01)00275-x. Bioorg Med Chem Lett. 2001. PMID: 11425547

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