Heffron H - Search Results

1

The role of insulin receptor substrate 2 in hypothalamic and beta cell function.

Choudhury AI, Heffron H, Smith MA, Al-Qassab H, Xu AW, Selman C, Simmgen M, Clements M, Claret M, Maccoll G, Bedford DC, Hisadome K, Diakonov I, Moosajee V, Bell JD, Speakman JR, Batterham RL, Barsh GS, Ashford ML, Withers DJ. Choudhury AI, et al. Among authors: heffron h. J Clin Invest. 2005 Apr;115(4):940-50. doi: 10.1172/JCI24445. Epub 2005 Mar 24. J Clin Invest. 2005. PMID: 15841180 Free PMC article.

2

Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice.

Simmgen M, Knauf C, Lopez M, Choudhury AI, Charalambous M, Cantley J, Bedford DC, Claret M, Iglesias MA, Heffron H, Cani PD, Vidal-Puig A, Burcelin R, Withers DJ. Simmgen M, et al. Among authors: heffron h. Diabetologia. 2006 Mar;49(3):552-61. doi: 10.1007/s00125-005-0084-4. Epub 2006 Jan 11. Diabetologia. 2006. PMID: 16404553

3

Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice.

Cantley J, Choudhury AI, Asare-Anane H, Selman C, Lingard S, Heffron H, Herrera P, Persaud SJ, Withers DJ. Cantley J, et al. Among authors: heffron h. Diabetologia. 2007 Jun;50(6):1248-56. doi: 10.1007/s00125-007-0637-9. Epub 2007 Mar 29. Diabetologia. 2007. PMID: 17393136 Free article.

4

Role of central nervous system and ovarian insulin receptor substrate 2 signaling in female reproductive function in the mouse.

Neganova I, Al-Qassab H, Heffron H, Selman C, Choudhury AI, Lingard SJ, Diakonov I, Patterson M, Ghatei M, Bloom SR, Franks S, Huhtaniemi I, Hardy K, Withers DJ. Neganova I, et al. Among authors: heffron h. Biol Reprod. 2007 Jun;76(6):1045-53. doi: 10.1095/biolreprod.106.059360. Epub 2007 Feb 28. Biol Reprod. 2007. PMID: 17329594

5

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.

Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LG, Clements M, Al-Qassab H, Heffron H, Xu AW, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford ML, Carling D, Withers DJ. Claret M, et al. Among authors: heffron h. J Clin Invest. 2007 Aug;117(8):2325-36. doi: 10.1172/JCI31516. J Clin Invest. 2007. PMID: 17671657 Free PMC article.

6

Critical role for peptide YY in protein-mediated satiation and body-weight regulation.

Batterham RL, Heffron H, Kapoor S, Chivers JE, Chandarana K, Herzog H, Le Roux CW, Thomas EL, Bell JD, Withers DJ. Batterham RL, et al. Among authors: heffron h. Cell Metab. 2006 Sep;4(3):223-33. doi: 10.1016/j.cmet.2006.08.001. Cell Metab. 2006. PMID: 16950139 Free article.

7

Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances.

Smith MA, Hisadome K, Al-Qassab H, Heffron H, Withers DJ, Ashford ML. Smith MA, et al. Among authors: heffron h. J Physiol. 2007 Jan 15;578(Pt 2):425-38. doi: 10.1113/jphysiol.2006.119479. Epub 2006 Oct 26. J Physiol. 2007. PMID: 17068101 Free PMC article.

8

Insulin-like peptide 5 is an orexigenic gastrointestinal hormone.

Grosse J, Heffron H, Burling K, Akhter Hossain M, Habib AM, Rogers GJ, Richards P, Larder R, Rimmington D, Adriaenssens AA, Parton L, Powell J, Binda M, Colledge WH, Doran J, Toyoda Y, Wade JD, Aparicio S, Carlton MB, Coll AP, Reimann F, O'Rahilly S, Gribble FM. Grosse J, et al. Among authors: heffron h. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11133-8. doi: 10.1073/pnas.1411413111. Epub 2014 Jul 15. Proc Natl Acad Sci U S A. 2014. PMID: 25028498 Free PMC article. Clinical Trial.

9

Selective FFA2 Agonism Appears to Act via Intestinal PYY to Reduce Transit and Food Intake but Does Not Improve Glucose Tolerance in Mouse Models.

Forbes S, Stafford S, Coope G, Heffron H, Real K, Newman R, Davenport R, Barnes M, Grosse J, Cox H. Forbes S, et al. Among authors: heffron h. Diabetes. 2015 Nov;64(11):3763-71. doi: 10.2337/db15-0481. Epub 2015 Aug 3. Diabetes. 2015. PMID: 26239054

10

Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2.

Tolhurst G, Heffron H, Lam YS, Parker HE, Habib AM, Diakogiannaki E, Cameron J, Grosse J, Reimann F, Gribble FM. Tolhurst G, et al. Among authors: heffron h. Diabetes. 2012 Feb;61(2):364-71. doi: 10.2337/db11-1019. Epub 2011 Dec 21. Diabetes. 2012. PMID: 22190648 Free PMC article.

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