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Discovery of a beta-MSH-derived MC-4R selective agonist.
Mayer JP, Hsiung HM, Flora DB, Edwards P, Smith DP, Zhang XY, Gadski RA, Heiman ML, Hertel JL, Emmerson PJ, Husain S, O'brien TP, Kahl SD, Smiley DL, Zhang L, Dimarchi RD, Yan LZ. Mayer JP, et al. Among authors: smiley dl. J Med Chem. 2005 May 5;48(9):3095-8. doi: 10.1021/jm0501432. J Med Chem. 2005. PMID: 15857110
Potent and selective MC-4 receptor agonists based on a novel disulfide scaffold.
Yan LZ, Flora D, Edwards P, Smiley DL, Emmerson PJ, Hsiung HM, Gadski R, Hertel J, Heiman ML, Husain S, O'Brien TP, Kahl SD, Zhang L, Dimarchi RD, Mayer JP. Yan LZ, et al. Among authors: smiley dl. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4611-4. doi: 10.1016/j.bmcl.2005.06.081. Bioorg Med Chem Lett. 2005. PMID: 16105738
A novel and selective beta-melanocyte-stimulating hormone-derived peptide agonist for melanocortin 4 receptor potently decreased food intake and body weight gain in diet-induced obese rats.
Hsiung HM, Hertel J, Zhang XY, Smith DP, Smiley DL, Heiman ML, Yang DD, Husain S, Mayer JP, Zhang L, Mo H, Yan LZ. Hsiung HM, et al. Among authors: smiley dl. Endocrinology. 2005 Dec;146(12):5257-66. doi: 10.1210/en.2005-0177. Epub 2005 Sep 15. Endocrinology. 2005. PMID: 16166226
37 results