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Discovery of a beta-MSH-derived MC-4R selective agonist.
Mayer JP, Hsiung HM, Flora DB, Edwards P, Smith DP, Zhang XY, Gadski RA, Heiman ML, Hertel JL, Emmerson PJ, Husain S, O'brien TP, Kahl SD, Smiley DL, Zhang L, Dimarchi RD, Yan LZ. Mayer JP, et al. Among authors: smith dp. J Med Chem. 2005 May 5;48(9):3095-8. doi: 10.1021/jm0501432. J Med Chem. 2005. PMID: 15857110
A novel and selective beta-melanocyte-stimulating hormone-derived peptide agonist for melanocortin 4 receptor potently decreased food intake and body weight gain in diet-induced obese rats.
Hsiung HM, Hertel J, Zhang XY, Smith DP, Smiley DL, Heiman ML, Yang DD, Husain S, Mayer JP, Zhang L, Mo H, Yan LZ. Hsiung HM, et al. Among authors: smith dp. Endocrinology. 2005 Dec;146(12):5257-66. doi: 10.1210/en.2005-0177. Epub 2005 Sep 15. Endocrinology. 2005. PMID: 16166226
Central H3R activation by thioperamide does not affect energy balance.
Sindelar DK, Shepperd ML, Pickard RT, Alexander-Chacko J, Dill MJ, Cramer JW, Smith DP, Gadski R. Sindelar DK, et al. Among authors: smith dp. Pharmacol Biochem Behav. 2004 Jun;78(2):275-83. doi: 10.1016/j.pbb.2004.03.019. Pharmacol Biochem Behav. 2004. PMID: 15219768
547 results