Mathvink R - Search Results

1

Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors.

Xu J, Wei L, Mathvink R, He J, Park YJ, He H, Leiting B, Lyons KA, Marsilio F, Patel RA, Wu JK, Thornberry NA, Weber AE. Xu J, et al. Among authors: mathvink r. Bioorg Med Chem Lett. 2005 May 16;15(10):2533-6. doi: 10.1016/j.bmcl.2005.03.055. Bioorg Med Chem Lett. 2005. PMID: 15863311

2

Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors.

Xu J, Wei L, Mathvink R, Edmondson SD, Mastracchio A, Eiermann GJ, He H, Leone JF, Leiting B, Lyons KA, Marsilio F, Patel RA, Petrov A, Wu JK, Thornberry NA, Weber AE. Xu J, et al. Among authors: mathvink r. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1346-9. doi: 10.1016/j.bmcl.2005.11.052. Epub 2005 Dec 5. Bioorg Med Chem Lett. 2006. PMID: 16332437

3

(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

Edmondson SD, Mastracchio A, Mathvink RJ, He J, Harper B, Park YJ, Beconi M, Di Salvo J, Eiermann GJ, He H, Leiting B, Leone JF, Levorse DA, Lyons K, Patel RA, Patel SB, Petrov A, Scapin G, Shang J, Roy RS, Smith A, Wu JK, Xu S, Zhu B, Thornberry NA, Weber AE. Edmondson SD, et al. Among authors: mathvink rj. J Med Chem. 2006 Jun 15;49(12):3614-27. doi: 10.1021/jm060015t. J Med Chem. 2006. PMID: 16759103

4

Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors.

Xu J, Wei L, Mathvink RJ, Edmondson SD, Eiermann GJ, He H, Leone JF, Leiting B, Lyons KA, Marsilio F, Patel RA, Patel SB, Petrov A, Scapin G, Wu JK, Thornberry NA, Weber AE. Xu J, et al. Among authors: mathvink rj. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5373-7. doi: 10.1016/j.bmcl.2006.07.061. Epub 2006 Aug 17. Bioorg Med Chem Lett. 2006. PMID: 16919457

5

Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes.

Chen P, Caldwell CG, Mathvink RJ, Leiting B, Marsilio F, Patel RA, Wu JK, He H, Lyons KA, Thornberry NA, Weber AE. Chen P, et al. Among authors: mathvink rj. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5853-7. doi: 10.1016/j.bmcl.2007.08.030. Epub 2007 Aug 19. Bioorg Med Chem Lett. 2007. PMID: 17869513

6

Potent, selective benzenesulfonamide agonists of the human beta 3 adrenergic receptor.

Weber AE, Mathvink RJ, Perkins L, Hutchins JE, Candelore MR, Tota L, Strader CD, Wyvratt MJ, Fisher MH. Weber AE, et al. Among authors: mathvink rj. Bioorg Med Chem Lett. 1998 May 5;8(9):1101-6. doi: 10.1016/s0960-894x(98)00169-3. Bioorg Med Chem Lett. 1998. PMID: 9871716

7

Potent, elective human beta3 adrenergic receptor agonists containing a substituted indoline-5-sulfonamide pharmacophore.

Mathvink RJ, Barritta AM, Candelore MR, Cascieri MA, Deng L, Tota L, Strader CD, Wyvratt MJ, Fisher MH, Weber AE. Mathvink RJ, et al. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1869-74. doi: 10.1016/s0960-894x(99)00277-2. Bioorg Med Chem Lett. 1999. PMID: 10406657

8

Potent, selective 3-pyridylethanolamine beta3 adrenergic receptor agonists possessing a thiazole benzenesulfonamide pharmacophore.

Mathvink RJ, Tolman JS, Chitty D, Candelore MR, Cascieri MA, Colwell LF Jr, Deng L, Feeney WP, Forrest MJ, Hom GJ, MacIntyre DE, Tota L, Wyvratt MJ, Fisher MH, Weber AE. Mathvink RJ, et al. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1971-3. doi: 10.1016/s0960-894x(00)00390-5. Bioorg Med Chem Lett. 2000. PMID: 10987429

9

Discovery of a potent, orally bioavailable beta(3) adrenergic receptor agonist, (R)-N-[4-[2-[[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4 -[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide.

Mathvink RJ, Tolman JS, Chitty D, Candelore MR, Cascieri MA, Colwell LF Jr, Deng L, Feeney WP, Forrest MJ, Hom GJ, MacIntyre DE, Miller RR, Stearns RA, Tota L, Wyvratt MJ, Fisher MH, Weber AE. Mathvink RJ, et al. J Med Chem. 2000 Oct 19;43(21):3832-6. doi: 10.1021/jm000286i. J Med Chem. 2000. PMID: 11052788

10

3-Pyridyloxypropanolamine agonists of the beta 3 adrenergic receptor with improved pharmacokinetic properties.

Weber AE, Ok HO, Alvaro RF, Candelore MR, Cascieri MA, Chiu SH, Deng L, Forrest MJ, Hom GJ, Hutchins JE, Kao J, MacIntyre DE, Mathvink RJ, McLoughlin D, Miller RR, Newbold RC, Olah TV, Parmee ER, Perkins L, Stearns RA, Strader CD, Szumiloski J, Tang YS, Tota L, Fisher MH, et al. Weber AE, et al. Among authors: mathvink rj. Bioorg Med Chem Lett. 1998 Aug 18;8(16):2111-6. doi: 10.1016/s0960-894x(98)00381-3. Bioorg Med Chem Lett. 1998. PMID: 9873496

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