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The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1).
Garcia-Calvo M, Lisnock J, Bull HG, Hawes BE, Burnett DA, Braun MP, Crona JH, Davis HR Jr, Dean DC, Detmers PA, Graziano MP, Hughes M, Macintyre DE, Ogawa A, O'neill KA, Iyer SP, Shevell DE, Smith MM, Tang YS, Makarewicz AM, Ujjainwalla F, Altmann SW, Chapman KT, Thornberry NA. Garcia-Calvo M, et al. Among authors: graziano mp. Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8132-7. doi: 10.1073/pnas.0500269102. Epub 2005 May 31. Proc Natl Acad Sci U S A. 2005. PMID: 15928087 Free PMC article.
Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis.
Davis HR Jr, Zhu LJ, Hoos LM, Tetzloff G, Maguire M, Liu J, Yao X, Iyer SP, Lam MH, Lund EG, Detmers PA, Graziano MP, Altmann SW. Davis HR Jr, et al. Among authors: graziano mp. J Biol Chem. 2004 Aug 6;279(32):33586-92. doi: 10.1074/jbc.M405817200. Epub 2004 Jun 1. J Biol Chem. 2004. PMID: 15173162 Free article.
Deficiency of Niemann-Pick C1 Like 1 prevents atherosclerosis in ApoE-/- mice.
Davis HR Jr, Hoos LM, Tetzloff G, Maguire M, Zhu LJ, Graziano MP, Altmann SW. Davis HR Jr, et al. Among authors: graziano mp. Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):841-9. doi: 10.1161/01.ATV.0000257627.40486.46. Epub 2007 Jan 11. Arterioscler Thromb Vasc Biol. 2007. PMID: 17218600
The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption.
Altmann SW, Davis HR Jr, Yao X, Laverty M, Compton DS, Zhu LJ, Crona JH, Caplen MA, Hoos LM, Tetzloff G, Priestley T, Burnett DA, Strader CD, Graziano MP. Altmann SW, et al. Among authors: graziano mp. Biochim Biophys Acta. 2002 Jan 30;1580(1):77-93. doi: 10.1016/s1388-1981(01)00190-1. Biochim Biophys Acta. 2002. PMID: 11923102
Tetrahydroisoquinolines as MCH-R1 antagonists.
Sasikumar TK, Qiang L, Wu WL, Burnett DA, Greenlee WJ, O'Neill K, Hawes BE, van Heek M, Graziano M. Sasikumar TK, et al. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4917-21. doi: 10.1016/j.bmcl.2006.06.055. Epub 2006 Jul 7. Bioorg Med Chem Lett. 2006. PMID: 16824753
59 results