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The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1).
Garcia-Calvo M, Lisnock J, Bull HG, Hawes BE, Burnett DA, Braun MP, Crona JH, Davis HR Jr, Dean DC, Detmers PA, Graziano MP, Hughes M, Macintyre DE, Ogawa A, O'neill KA, Iyer SP, Shevell DE, Smith MM, Tang YS, Makarewicz AM, Ujjainwalla F, Altmann SW, Chapman KT, Thornberry NA. Garcia-Calvo M, et al. Among authors: hawes be. Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8132-7. doi: 10.1073/pnas.0500269102. Epub 2005 May 31. Proc Natl Acad Sci U S A. 2005. PMID: 15928087 Free PMC article.
Tetrahydroisoquinolines as MCH-R1 antagonists.
Sasikumar TK, Qiang L, Wu WL, Burnett DA, Greenlee WJ, O'Neill K, Hawes BE, van Heek M, Graziano M. Sasikumar TK, et al. Among authors: hawes be. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4917-21. doi: 10.1016/j.bmcl.2006.06.055. Epub 2006 Jul 7. Bioorg Med Chem Lett. 2006. PMID: 16824753
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