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The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1).
Garcia-Calvo M, Lisnock J, Bull HG, Hawes BE, Burnett DA, Braun MP, Crona JH, Davis HR Jr, Dean DC, Detmers PA, Graziano MP, Hughes M, Macintyre DE, Ogawa A, O'neill KA, Iyer SP, Shevell DE, Smith MM, Tang YS, Makarewicz AM, Ujjainwalla F, Altmann SW, Chapman KT, Thornberry NA. Garcia-Calvo M, et al. Among authors: makarewicz am. Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8132-7. doi: 10.1073/pnas.0500269102. Epub 2005 May 31. Proc Natl Acad Sci U S A. 2005. PMID: 15928087 Free PMC article.
Discovery of potent and selective orally bioavailable beta-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors.
Edmondson SD, Mastracchio A, Duffy JL, Eiermann GJ, He H, Ita I, Leiting B, Leone JF, Lyons KA, Makarewicz AM, Patel RA, Petrov A, Wu JK, Thornberry NA, Weber AE. Edmondson SD, et al. Among authors: makarewicz am. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3048-52. doi: 10.1016/j.bmcl.2005.04.028. Bioorg Med Chem Lett. 2005. PMID: 15908206
Accelerating Pharmaceutical Process Development with an Acoustic Droplet Ejection-Multiple Reaction Monitoring-Mass Spectrometry Workflow.
Hu H, Singh AN, Lehnherr D, Mdluli V, Chun SW, Makarewicz AM, Gouker JR, Ukaegbu O, Li S, Wen X, McLaren DG, Velasquez JE, Moore JC, Galanie S, Appiah-Amponsah E, Regalado EL. Hu H, et al. Among authors: makarewicz am. Anal Chem. 2024 Jan 23;96(3):1138-1146. doi: 10.1021/acs.analchem.3c04211. Epub 2024 Jan 2. Anal Chem. 2024. PMID: 38165811