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Heparanase promotes the spontaneous metastasis of myeloma cells to bone.
Yang Y, Macleod V, Bendre M, Huang Y, Theus AM, Miao HQ, Kussie P, Yaccoby S, Epstein J, Suva LJ, Kelly T, Sanderson RD. Yang Y, et al. Among authors: macleod v. Blood. 2005 Feb 1;105(3):1303-9. doi: 10.1182/blood-2004-06-2141. Epub 2004 Oct 7. Blood. 2005. PMID: 15471949 Free article.
HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo.
Dai Y, Yang Y, MacLeod V, Yue X, Rapraeger AC, Shriver Z, Venkataraman G, Sasisekharan R, Sanderson RD. Dai Y, et al. Among authors: macleod v. J Biol Chem. 2005 Dec 2;280(48):40066-73. doi: 10.1074/jbc.M508136200. Epub 2005 Sep 27. J Biol Chem. 2005. PMID: 16192265 Free article.
The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy.
Yang Y, MacLeod V, Dai Y, Khotskaya-Sample Y, Shriver Z, Venkataraman G, Sasisekharan R, Naggi A, Torri G, Casu B, Vlodavsky I, Suva LJ, Epstein J, Yaccoby S, Shaughnessy JD Jr, Barlogie B, Sanderson RD. Yang Y, et al. Among authors: macleod v. Blood. 2007 Sep 15;110(6):2041-8. doi: 10.1182/blood-2007-04-082495. Epub 2007 May 29. Blood. 2007. PMID: 17536013 Free PMC article.
34 results