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Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitors.
Dublanchet AC, Ducrot P, Andrianjara C, O'Gara M, Morales R, Compère D, Denis A, Blais S, Cluzeau P, Courté K, Hamon J, Moreau F, Prunet ML, Tertre A. Dublanchet AC, et al. Among authors: denis a. Bioorg Med Chem Lett. 2005 Aug 15;15(16):3787-90. doi: 10.1016/j.bmcl.2005.05.079. Bioorg Med Chem Lett. 2005. PMID: 16002291
Towards Gram-negative antivirulence drugs: new inhibitors of HldE kinase.
Desroy N, Moreau F, Briet S, Le Fralliec G, Floquet S, Durant L, Vongsouthi V, Gerusz V, Denis A, Escaich S. Desroy N, et al. Among authors: denis a. Bioorg Med Chem. 2009 Feb 1;17(3):1276-89. doi: 10.1016/j.bmc.2008.12.021. Epub 2008 Dec 24. Bioorg Med Chem. 2009. PMID: 19124251
Novel HldE-K inhibitors leading to attenuated Gram negative bacterial virulence.
Desroy N, Denis A, Oliveira C, Atamanyuk D, Briet S, Faivre F, LeFralliec G, Bonvin Y, Oxoby M, Escaich S, Floquet S, Drocourt E, Vongsouthi V, Durant L, Moreau F, Verhey TB, Lee TW, Junop MS, Gerusz V. Desroy N, et al. Among authors: denis a. J Med Chem. 2013 Feb 28;56(4):1418-30. doi: 10.1021/jm301499r. Epub 2013 Feb 14. J Med Chem. 2013. PMID: 23409840
From triclosan toward the clinic: discovery of nonbiocidal, potent FabI inhibitors for the treatment of resistant bacteria.
Gerusz V, Denis A, Faivre F, Bonvin Y, Oxoby M, Briet S, LeFralliec G, Oliveira C, Desroy N, Raymond C, Peltier L, Moreau F, Escaich S, Vongsouthi V, Floquet S, Drocourt E, Walton A, Prouvensier L, Saccomani M, Durant L, Genevard JM, Sam-Sambo V, Soulama-Mouze C. Gerusz V, et al. Among authors: denis a. J Med Chem. 2012 Nov 26;55(22):9914-28. doi: 10.1021/jm301113w. Epub 2012 Oct 23. J Med Chem. 2012. PMID: 23092194
Structural-functional studies of Burkholderia cenocepacia D-glycero-β-D-manno-heptose 7-phosphate kinase (HldA) and characterization of inhibitors with antibiotic adjuvant and antivirulence properties.
Lee TW, Verhey TB, Antiperovitch PA, Atamanyuk D, Desroy N, Oliveira C, Denis A, Gerusz V, Drocourt E, Loutet SA, Hamad MA, Stanetty C, Andres SN, Sugiman-Marangos S, Kosma P, Valvano MA, Moreau F, Junop MS. Lee TW, et al. Among authors: denis a. J Med Chem. 2013 Feb 28;56(4):1405-17. doi: 10.1021/jm301483h. Epub 2013 Jan 22. J Med Chem. 2013. PMID: 23256532 Free PMC article.
The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.
Liddle J, Beaufils B, Binnie M, Bouillot A, Denis AA, Hann MM, Haslam CP, Holmes DS, Hutchinson JP, Kranz M, McBride A, Mirguet O, Mole DJ, Mowat CG, Pal S, Rowland P, Trottet L, Uings IJ, Walker AL, Webster SP. Liddle J, et al. Among authors: denis aa. Bioorg Med Chem Lett. 2017 May 1;27(9):2023-2028. doi: 10.1016/j.bmcl.2017.02.078. Epub 2017 Mar 9. Bioorg Med Chem Lett. 2017. PMID: 28336141 Free article.
476 results