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Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes.
Meyre D, Bouatia-Naji N, Tounian A, Samson C, Lecoeur C, Vatin V, Ghoussaini M, Wachter C, Hercberg S, Charpentier G, Patsch W, Pattou F, Charles MA, Tounian P, Clément K, Jouret B, Weill J, Maddux BA, Goldfine ID, Walley A, Boutin P, Dina C, Froguel P. Meyre D, et al. Among authors: tounian p, tounian a. Nat Genet. 2005 Aug;37(8):863-7. doi: 10.1038/ng1604. Epub 2005 Jul 17. Nat Genet. 2005. PMID: 16025115 Free PMC article.
Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity.
Ghoussaini M, Vatin V, Lecoeur C, Abkevich V, Younus A, Samson C, Wachter C, Heude B, Tauber M, Tounian P, Hercberg S, Weill J, Levy-Marchal C, Le Stunff C, Bougnères P, Froguel P, Meyre D. Ghoussaini M, et al. Among authors: tounian p. J Clin Endocrinol Metab. 2007 Nov;92(11):4403-9. doi: 10.1210/jc.2006-2316. Epub 2007 Aug 14. J Clin Endocrinol Metab. 2007. PMID: 17698913
Analysis of the SIM1 contribution to polygenic obesity in the French population.
Ghoussaini M, Stutzmann F, Couturier C, Vatin V, Durand E, Lecoeur C, Degraeve F, Heude B, Tauber M, Hercberg S, Levy-Marchal C, Tounian P, Weill J, Traurig M, Bogardus C, Baier LJ, Michaud JL, Froguel P, Meyre D. Ghoussaini M, et al. Among authors: tounian p. Obesity (Silver Spring). 2010 Aug;18(8):1670-5. doi: 10.1038/oby.2009.468. Epub 2010 Jan 14. Obesity (Silver Spring). 2010. PMID: 20075856 Free PMC article.
Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain.
Dubern B, Lubrano-Berthelier C, Mencarelli M, Ersoy B, Frelut ML, Bouglé D, Costes B, Simon C, Tounian P, Vaisse C, Clement K. Dubern B, et al. Among authors: tounian p. Pediatr Res. 2008 Feb;63(2):211-6. doi: 10.1203/PDR.0b013e31815ed62b. Pediatr Res. 2008. PMID: 18091355
150 results