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Cohesinopathy mutations disrupt the subnuclear organization of chromatin.
Gard S, Light W, Xiong B, Bose T, McNairn AJ, Harris B, Fleharty B, Seidel C, Brickner JH, Gerton JL. Gard S, et al. Among authors: mcnairn aj. J Cell Biol. 2009 Nov 16;187(4):455-62. doi: 10.1083/jcb.200906075. Epub 2009 Nov 9. J Cell Biol. 2009. PMID: 19948494 Free PMC article.
The chromosome glue gets a little stickier.
McNairn AJ, Gerton JL. McNairn AJ, et al. Trends Genet. 2008 Aug;24(8):382-9. doi: 10.1016/j.tig.2008.06.002. Epub 2008 Jul 2. Trends Genet. 2008. PMID: 18602182 Review.
Cohesinopathies: One ring, many obligations.
McNairn AJ, Gerton JL. McNairn AJ, et al. Mutat Res. 2008 Dec 1;647(1-2):103-11. doi: 10.1016/j.mrfmmm.2008.08.010. Epub 2008 Aug 22. Mutat Res. 2008. PMID: 18786550 Review.
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