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Synthesis and structure-activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors.
Ouyang X, Chen X, Piatnitski EL, Kiselyov AS, He HY, Mao Y, Pattaropong V, Yu Y, Kim KH, Kincaid J, Smith L 2nd, Wong WC, Lee SP, Milligan DL, Malikzay A, Fleming J, Gerlak J, Deevi D, Doody JF, Chiang HH, Patel SN, Wang Y, Rolser RL, Kussie P, Labelle M, Tuma MC. Ouyang X, et al. Among authors: kim kh. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5154-9. doi: 10.1016/j.bmcl.2005.08.056. Epub 2005 Sep 28. Bioorg Med Chem Lett. 2005. PMID: 16198562
Novel tricyclic azepine derivatives: Biological evaluation of pyrimido[4,5-b]-1,4-benzoxazepines, thiazepines, and diazepines as inhibitors of the epidermal growth factor receptor tyrosine kinase.
Smith L 2nd, Wong WC, Kiselyov AS, Burdzovic-Wizemann S, Mao Y, Xu Y, Duncton MA, Kim K, Piatnitski EL, Doody JF, Wang Y, Rosler RL, Milligan D, Columbus J, Balagtas C, Lee SP, Konovalov A, Hadari YR. Smith L 2nd, et al. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5102-6. doi: 10.1016/j.bmcl.2006.07.031. Epub 2006 Aug 2. Bioorg Med Chem Lett. 2006. PMID: 16887347
Synthesis and biological evaluation of 2-indolyloxazolines as a new class of tubulin polymerization inhibitors. Discovery of A-289099 as an orally active antitumor agent.
Li Q, Woods KW, Claiborne A, Gwaltney SL 2nd, Barr KJ, Liu G, Gehrke L, Credo RB, Hui YH, Lee J, Warner RB, Kovar P, Nukkala MA, Zielinski NA, Tahir SK, Fitzgerald M, Kim KH, Marsh K, Frost D, Ng SC, Rosenberg S, Sham HL. Li Q, et al. Among authors: kim kh. Bioorg Med Chem Lett. 2002 Feb 11;12(3):465-9. doi: 10.1016/s0960-894x(01)00759-4. Bioorg Med Chem Lett. 2002. PMID: 11814821
Pyridopyrimidine analogues as novel adenosine kinase inhibitors.
Zheng GZ, Lee C, Pratt JK, Perner RJ, Jiang MQ, Gomtsyan A, Matulenko MA, Mao Y, Koenig JR, Kim KH, Muchmore S, Yu H, Kohlhaas K, Alexander KM, McGaraughty S, Chu KL, Wismer CT, Mikusa J, Jarvis MF, Marsh K, Kowaluk EA, Bhagwat SS, Stewart AO. Zheng GZ, et al. Among authors: kim kh. Bioorg Med Chem Lett. 2001 Aug 20;11(16):2071-4. doi: 10.1016/s0960-894x(01)00375-4. Bioorg Med Chem Lett. 2001. PMID: 11514141
From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells.
Gaisina IN, Gallier F, Ougolkov AV, Kim KH, Kurome T, Guo S, Holzle D, Luchini DN, Blond SY, Billadeau DD, Kozikowski AP. Gaisina IN, et al. Among authors: kim kh. J Med Chem. 2009 Apr 9;52(7):1853-63. doi: 10.1021/jm801317h. J Med Chem. 2009. PMID: 19338355 Free PMC article.
Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
Sheppard GS, Wang J, Kawai M, Fidanze SD, BaMaung NY, Erickson SA, Barnes DM, Tedrow JS, Kolaczkowski L, Vasudevan A, Park DC, Wang GT, Sanders WJ, Mantei RA, Palazzo F, Tucker-Garcia L, Lou P, Zhang Q, Park CH, Kim KH, Petros A, Olejniczak E, Nettesheim D, Hajduk P, Henkin J, Lesniewski R, Davidsen SK, Bell RL. Sheppard GS, et al. Among authors: kim kh. J Med Chem. 2006 Jun 29;49(13):3832-49. doi: 10.1021/jm0601001. J Med Chem. 2006. PMID: 16789740
10,249 results
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