Baillie TA - Search Results

1

Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.

Chen Q, Doss GA, Tung EC, Liu W, Tang YS, Braun MP, Didolkar V, Strauss JR, Wang RW, Stearns RA, Evans DC, Baillie TA, Tang W. Chen Q, et al. Among authors: baillie ta. Drug Metab Dispos. 2006 Jan;34(1):145-51. doi: 10.1124/dmd.105.004341. Epub 2005 Oct 26. Drug Metab Dispos. 2006. PMID: 16251255

2

Identification in rat bile of glutathione conjugates of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether, a nephrotoxic degradate of the anesthetic agent sevoflurane.

Jin L, Davis MR, Kharasch ED, Doss GA, Baillie TA. Jin L, et al. Among authors: baillie ta. Chem Res Toxicol. 1996 Mar;9(2):555-61. doi: 10.1021/tx950162m. Chem Res Toxicol. 1996. PMID: 8839062

3

In vitro and in vivo evaluations of the metabolism, pharmacokinetics, and bioavailability of ester prodrugs of L-767,679, a potent fibrinogen receptor antagonist: an approach for the selection of a prodrug candidate.

Prueksaritanont T, Gorham LM, Breslin MJ, Hutchinson JH, Hartman GD, Vyas KP, Baillie TA. Prueksaritanont T, et al. Among authors: baillie ta. Drug Metab Dispos. 1997 Aug;25(8):978-84. Drug Metab Dispos. 1997. PMID: 9280406

4

Metabolic profiles of montelukast sodium (Singulair), a potent cysteinyl leukotriene1 receptor antagonist, in human plasma and bile.

Balani SK, Xu X, Pratha V, Koss MA, Amin RD, Dufresne C, Miller RR, Arison BH, Doss GA, Chiba M, Freeman A, Holland SD, Schwartz JI, Lasseter KC, Gertz BJ, Isenberg JI, Rogers JD, Lin JH, Baillie TA. Balani SK, et al. Among authors: baillie ta. Drug Metab Dispos. 1997 Nov;25(11):1282-7. Drug Metab Dispos. 1997. PMID: 9351905 Clinical Trial.

5

Roles of human hepatic cytochrome P450s 2C9 and 3A4 in the metabolic activation of diclofenac.

Tang W, Stearns RA, Wang RW, Chiu SH, Baillie TA. Tang W, et al. Among authors: baillie ta. Chem Res Toxicol. 1999 Feb;12(2):192-9. doi: 10.1021/tx9802217. Chem Res Toxicol. 1999. PMID: 10027798

6

Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.

Tang W, Stearns RA, Bandiera SM, Zhang Y, Raab C, Braun MP, Dean DC, Pang J, Leung KH, Doss GA, Strauss JR, Kwei GY, Rushmore TH, Chiu SH, Baillie TA. Tang W, et al. Among authors: baillie ta. Drug Metab Dispos. 1999 Mar;27(3):365-72. Drug Metab Dispos. 1999. PMID: 10064567

7

Rapid liquid chromatography with tandem mass spectrometry-based screening procedures for studies on the biotransformation of drug candidates.

Fernández-Metzler CL, Owens KG, Baillie TA, King RC. Fernández-Metzler CL, et al. Among authors: baillie ta. Drug Metab Dispos. 1999 Jan;27(1):32-40. Drug Metab Dispos. 1999. PMID: 10068285

8

Interaction of diclofenac and quinidine in monkeys: stimulation of diclofenac metabolism.

Tang W, Stearns RA, Kwei GY, Iliff SA, Miller RR, Egan MA, Yu NX, Dean DC, Kumar S, Shou M, Lin JH, Baillie TA. Tang W, et al. Among authors: baillie ta. J Pharmacol Exp Ther. 1999 Dec;291(3):1068-74. J Pharmacol Exp Ther. 1999. PMID: 10565826

9

Metabolism of A dopamine D(4)-selective antagonist in rat, monkey, and humans: formation of A novel mercapturic acid adduct.

Zhang KE, Kari PH, Davis MR, Doss G, Baillie TA, Vyas KP. Zhang KE, et al. Among authors: baillie ta. Drug Metab Dispos. 2000 Jun;28(6):633-42. Drug Metab Dispos. 2000. PMID: 10820134

10

Cytochrome P450 3A4-mediated interaction of diclofenac and quinidine.

Ngui JS, Tang W, Stearns RA, Shou M, Miller RR, Zhang Y, Lin JH, Baillie TA. Ngui JS, et al. Among authors: baillie ta. Drug Metab Dispos. 2000 Sep;28(9):1043-50. Drug Metab Dispos. 2000. PMID: 10950847

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