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Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts.
Pawitan Y, Bjöhle J, Amler L, Borg AL, Egyhazi S, Hall P, Han X, Holmberg L, Huang F, Klaar S, Liu ET, Miller L, Nordgren H, Ploner A, Sandelin K, Shaw PM, Smeds J, Skoog L, Wedrén S, Bergh J. Pawitan Y, et al. Among authors: amler l. Breast Cancer Res. 2005;7(6):R953-64. doi: 10.1186/bcr1325. Epub 2005 Oct 3. Breast Cancer Res. 2005. PMID: 16280042 Free PMC article.
Gene expression profiling for prognosis using Cox regression.
Pawitan Y, Bjöhle J, Wedren S, Humphreys K, Skoog L, Huang F, Amler L, Shaw P, Hall P, Bergh J. Pawitan Y, et al. Among authors: amler l. Stat Med. 2004 Jun 15;23(11):1767-80. doi: 10.1002/sim.1769. Stat Med. 2004. PMID: 15160407
Biomarker analysis of the NeoSphere study: pertuzumab, trastuzumab, and docetaxel versus trastuzumab plus docetaxel, pertuzumab plus trastuzumab, or pertuzumab plus docetaxel for the neoadjuvant treatment of HER2-positive breast cancer.
Bianchini G, Kiermaier A, Bianchi GV, Im YH, Pienkowski T, Liu MC, Tseng LM, Dowsett M, Zabaglo L, Kirk S, Szado T, Eng-Wong J, Amler LC, Valagussa P, Gianni L. Bianchini G, et al. Among authors: amler lc. Breast Cancer Res. 2017 Feb 9;19(1):16. doi: 10.1186/s13058-017-0806-9. Breast Cancer Res. 2017. PMID: 28183321 Free PMC article. Clinical Trial.
Relationship between HER2 expression and efficacy with first-line trastuzumab emtansine compared with trastuzumab plus docetaxel in TDM4450g: a randomized phase II study of patients with previously untreated HER2-positive metastatic breast cancer.
Perez EA, Hurvitz SA, Amler LC, Mundt KE, Ng V, Guardino E, Gianni L. Perez EA, et al. Among authors: amler lc. Breast Cancer Res. 2014 May 23;16(3):R50. doi: 10.1186/bcr3661. Breast Cancer Res. 2014. PMID: 24887458 Free PMC article. Clinical Trial.
Gene Expression Profiling in BRAF-Mutated Melanoma Reveals Patient Subgroups with Poor Outcomes to Vemurafenib That May Be Overcome by Cobimetinib Plus Vemurafenib.
Wongchenko MJ, McArthur GA, Dréno B, Larkin J, Ascierto PA, Sosman J, Andries L, Kockx M, Hurst SD, Caro I, Rooney I, Hegde PS, Molinero L, Yue H, Chang I, Amler L, Yan Y, Ribas A. Wongchenko MJ, et al. Among authors: amler l. Clin Cancer Res. 2017 Sep 1;23(17):5238-5245. doi: 10.1158/1078-0432.CCR-17-0172. Epub 2017 May 23. Clin Cancer Res. 2017. PMID: 28536307
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