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Supranormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure: insights from creatine transporter-overexpressing transgenic mice.
Wallis J, Lygate CA, Fischer A, ten Hove M, Schneider JE, Sebag-Montefiore L, Dawson D, Hulbert K, Zhang W, Zhang MH, Watkins H, Clarke K, Neubauer S. Wallis J, et al. Circulation. 2005 Nov 15;112(20):3131-9. doi: 10.1161/CIRCULATIONAHA.105.572990. Circulation. 2005. PMID: 16286605
Reduced inotropic reserve and increased susceptibility to cardiac ischemia/reperfusion injury in phosphocreatine-deficient guanidinoacetate-N-methyltransferase-knockout mice.
ten Hove M, Lygate CA, Fischer A, Schneider JE, Sang AE, Hulbert K, Sebag-Montefiore L, Watkins H, Clarke K, Isbrandt D, Wallis J, Neubauer S. ten Hove M, et al. Circulation. 2005 May 17;111(19):2477-85. doi: 10.1161/01.CIR.0000165147.99592.01. Epub 2005 May 9. Circulation. 2005. PMID: 15883212
Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity.
Phillips D, Ten Hove M, Schneider JE, Wu CO, Sebag-Montefiore L, Aponte AM, Lygate CA, Wallis J, Clarke K, Watkins H, Balaban RS, Neubauer S. Phillips D, et al. Among authors: sebag montefiore l. J Mol Cell Cardiol. 2010 Apr;48(4):582-90. doi: 10.1016/j.yjmcc.2009.10.033. Epub 2009 Nov 11. J Mol Cell Cardiol. 2010. PMID: 19913546 Free PMC article.
Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction.
Lygate CA, Bohl S, ten Hove M, Faller KM, Ostrowski PJ, Zervou S, Medway DJ, Aksentijevic D, Sebag-Montefiore L, Wallis J, Clarke K, Watkins H, Schneider JE, Neubauer S. Lygate CA, et al. Among authors: sebag montefiore l. Cardiovasc Res. 2012 Dec 1;96(3):466-75. doi: 10.1093/cvr/cvs272. Epub 2012 Aug 21. Cardiovasc Res. 2012. PMID: 22915766 Free PMC article.
Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice.
Lygate CA, Aksentijevic D, Dawson D, ten Hove M, Phillips D, de Bono JP, Medway DJ, Sebag-Montefiore L, Hunyor I, Channon KM, Clarke K, Zervou S, Watkins H, Balaban RS, Neubauer S. Lygate CA, et al. Among authors: sebag montefiore l. Circ Res. 2013 Mar 15;112(6):945-55. doi: 10.1161/CIRCRESAHA.112.300725. Epub 2013 Jan 16. Circ Res. 2013. PMID: 23325497 Free PMC article.
Creatine uptake in mouse hearts with genetically altered creatine levels.
ten Hove M, Makinen K, Sebag-Montefiore L, Hunyor I, Fischer A, Wallis J, Isbrandt D, Lygate C, Neubauer S. ten Hove M, et al. J Mol Cell Cardiol. 2008 Sep;45(3):453-9. doi: 10.1016/j.yjmcc.2008.05.023. Epub 2008 Jun 10. J Mol Cell Cardiol. 2008. PMID: 18602925 Free PMC article.
22 results