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Steroidal and triterpenoidal fungal metabolites as ligands of liver X receptors.
Ondeyka JG, Jayasuriya H, Herath KB, Guan Z, Schulman M, Collado J, Dombrowski AW, Kwon SS, McCallum C, Sharma N, MacNaul K, Hayes N, Menke JG, Singh SB. Ondeyka JG, et al. Among authors: hayes n. J Antibiot (Tokyo). 2005 Sep;58(9):559-65. doi: 10.1038/ja.2005.76. J Antibiot (Tokyo). 2005. PMID: 16320760
Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources.
Jayasuriya H, Herath KB, Ondeyka JG, Guan Z, Borris RP, Tiwari S, de Jong W, Chavez F, Moss J, Stevenson DW, Beck HT, Slattery M, Zamora N, Schulman M, Ali A, Sharma N, MacNaul K, Hayes N, Menke JG, Singh SB. Jayasuriya H, et al. Among authors: hayes n. J Nat Prod. 2005 Aug;68(8):1247-52. doi: 10.1021/np050182g. J Nat Prod. 2005. PMID: 16124770
Design, synthesis, and structure-activity relationship of podocarpic acid amides as liver X receptor agonists for potential treatment of atherosclerosis.
Liu W, Chen S, Dropinski J, Colwell L, Robins M, Szymonifka M, Hayes N, Sharma N, MacNaul K, Hernandez M, Burton C, Sparrow CP, Menke JG, Singh SB. Liu W, et al. Among authors: hayes n. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4574-8. doi: 10.1016/j.bmcl.2005.06.100. Bioorg Med Chem Lett. 2005. PMID: 16125384
A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux.
Sparrow CP, Baffic J, Lam MH, Lund EG, Adams AD, Fu X, Hayes N, Jones AB, Macnaul KL, Ondeyka J, Singh S, Wang J, Zhou G, Moller DE, Wright SD, Menke JG. Sparrow CP, et al. Among authors: hayes n. J Biol Chem. 2002 Mar 22;277(12):10021-7. doi: 10.1074/jbc.M108225200. Epub 2002 Jan 14. J Biol Chem. 2002. PMID: 11790770 Free article.
Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters.
Singh SB, Ondeyka JG, Liu W, Chen S, Chen TS, Li X, Bouffard A, Dropinski J, Jones AB, McCormick S, Hayes N, Wang J, Sharma N, Macnaul K, Hernandez M, Chao YS, Baffic J, Lam MH, Burton C, Sparrow CP, Menke JG. Singh SB, et al. Among authors: hayes n. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2824-8. doi: 10.1016/j.bmcl.2005.03.100. Bioorg Med Chem Lett. 2005. PMID: 15911262
Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors.
Chu L, Armstrong HM, Chang LL, Cheng AF, Colwell L, Cui J, Evans J, Galka A, Goulet MT, Hayes N, Lo J, Menke J, Ok HO, Ondeyka DL, Patel M, Quaker GM, Sings H, Witkin SL, Zhao A, Ujjainwalla F. Chu L, et al. Among authors: hayes n. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4133-8. doi: 10.1016/j.bmcl.2012.04.064. Epub 2012 Apr 20. Bioorg Med Chem Lett. 2012. PMID: 22578458
Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects.
Berger J, Leibowitz MD, Doebber TW, Elbrecht A, Zhang B, Zhou G, Biswas C, Cullinan CA, Hayes NS, Li Y, Tanen M, Ventre J, Wu MS, Berger GD, Mosley R, Marquis R, Santini C, Sahoo SP, Tolman RL, Smith RG, Moller DE. Berger J, et al. Among authors: hayes ns. J Biol Chem. 1999 Mar 5;274(10):6718-25. doi: 10.1074/jbc.274.10.6718. J Biol Chem. 1999. PMID: 10037770 Free article.
518 results