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Genomewide scan and fine-mapping linkage studies in four European samples with bipolar affective disorder suggest a new susceptibility locus on chromosome 1p35-p36 and provides further evidence of loci on chromosome 4q31 and 6q24.
Schumacher J, Kaneva R, Jamra RA, Diaz GO, Ohlraun S, Milanova V, Lee YA, Rivas F, Mayoral F, Fuerst R, Flaquer A, Windemuth C, Gay E, Sanz S, González MJ, Gil S, Cabaleiro F, del Rio F, Perez F, Haro J, Kostov C, Chorbov V, Nikolova-Hill A, Stoyanova V, Onchev G, Kremensky I, Strauch K, Schulze TG, Nürnberg P, Gaebel W, Klimke A, Auburger G, Wienker TF, Kalaydjieva L, Propping P, Cichon S, Jablensky A, Rietschel M, Nöthen MM. Schumacher J, et al. Among authors: kostov c. Am J Hum Genet. 2005 Dec;77(6):1102-11. doi: 10.1086/498619. Epub 2005 Nov 2. Am J Hum Genet. 2005. PMID: 16380920 Free PMC article.
The first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder: strong evidence of epistatic effects between loci on chromosomes 2q and 6q.
Abou Jamra R, Fuerst R, Kaneva R, Orozco Diaz G, Rivas F, Mayoral F, Gay E, Sans S, Gonzalez MJ, Gil S, Cabaleiro F, Del Rio F, Perez F, Haro J, Auburger G, Milanova V, Kostov C, Chorbov V, Stoyanova V, Nikolova-Hill A, Onchev G, Kremensky I, Jablensky A, Schulze TG, Propping P, Rietschel M, Nothen MM, Cichon S, Wienker TF, Schumacher J. Abou Jamra R, et al. Among authors: kostov c. Am J Hum Genet. 2007 Nov;81(5):974-86. doi: 10.1086/521690. Epub 2007 Sep 17. Am J Hum Genet. 2007. PMID: 17924339 Free PMC article.
Linkage analysis in bipolar pedigrees adds support for a susceptibility locus on 21q22.
Kaneva RP, Chorbov VM, Milanova VK, Kostov CS, Nickolov KI, Chakarova CF, Stoyanova VS, Nikolova-Hill AN, Krastev SK, Onchev GN, Kremensky IM, Kalaydjieva LV, Jablensky AV. Kaneva RP, et al. Among authors: kostov cs. Psychiatr Genet. 2004 Jun;14(2):101-6. doi: 10.1097/01.ypg.0000128766.92096.ad. Psychiatr Genet. 2004. PMID: 15167697
Bipolar disorder in the Bulgarian Gypsies: genetic heterogeneity in a young founder population.
Kaneva R, Milanova V, Angelicheva D, MacGregor S, Kostov C, Vladimirova R, Aleksiev S, Angelova M, Stoyanova V, Loh A, Hallmayer J, Kalaydjieva L, Jablensky A. Kaneva R, et al. Among authors: kostov c. Am J Med Genet B Neuropsychiatr Genet. 2009 Mar 5;150B(2):191-201. doi: 10.1002/ajmg.b.30775. Am J Med Genet B Neuropsychiatr Genet. 2009. PMID: 18444255
Evidence of an association between bipolar disorder and rs16917237 in the BDNF gene in a Bulgarian sample.
Ivanova MA, Christova TN, Asan TS, Djurova NA, Alexiev SS, Kostov CS, Chorbov VM, Stoyanova VS, Onchev GN, Kancheva DM, Krastev SK, Vladimirova RK, Kremensky IM, Mitev V, Milanova VK, Kaneva RP. Ivanova MA, et al. Among authors: kostov cs. Psychiatr Genet. 2013 Jun;23(3):141-2. doi: 10.1097/YPG.0b013e32835d7225. Psychiatr Genet. 2013. PMID: 23277136 No abstract available.