Peterson MA - Search Results

1

Synthesis and biological evaluation of 6-(alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one base and nucleoside derivatives.

Robins MJ, Miranda K, Rajwanshi VK, Peterson MA, Andrei G, Snoeck R, De Clercq E, Balzarini J. Robins MJ, et al. Among authors: peterson ma. J Med Chem. 2006 Jan 12;49(1):391-8. doi: 10.1021/jm050867d. J Med Chem. 2006. PMID: 16392824

2

Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core.

Robins MJ, Nowak I, Rajwanshi VK, Miranda K, Cannon JF, Peterson MA, Andrei G, Snoeck R, De Clercq E, Balzarini J. Robins MJ, et al. Among authors: peterson ma. J Med Chem. 2007 Aug 9;50(16):3897-905. doi: 10.1021/jm070210n. Epub 2007 Jul 10. J Med Chem. 2007. PMID: 17622128

3

Synthesis and biological evaluation of 3,3-difluoropyridine-2,4(1H,3H)-dione and 3-deaza-3-fluorouracil base and nucleoside derivatives.

Robins MJ, Yang H, Miranda K, Peterson MA, De Clercq E, Balzarini J. Robins MJ, et al. Among authors: peterson ma. J Med Chem. 2009 May 14;52(9):3018-27. doi: 10.1021/jm900203h. J Med Chem. 2009. PMID: 19378989

4

Synthesis, SAR, and preliminary mechanistic evaluation of novel antiproliferative N⁶,5'-bis-ureido- and 5'-carbamoyl-N⁶-ureidoadenosine derivatives.

Shelton JR, Cutler CE, Oliveira M, Balzarini J, Peterson MA. Shelton JR, et al. Among authors: peterson ma. Bioorg Med Chem. 2012 Jan 15;20(2):1008-19. doi: 10.1016/j.bmc.2011.11.043. Epub 2011 Dec 2. Bioorg Med Chem. 2012. PMID: 22189274

5

Discovery of a nanomolar inhibitor of lung adenocarcinoma in vitro.

Shelton JR, Balzarini J, Peterson MA. Shelton JR, et al. Among authors: peterson ma. Bioorg Med Chem Lett. 2014 Nov 1;24(21):5107-10. doi: 10.1016/j.bmcl.2014.08.044. Epub 2014 Sep 3. Bioorg Med Chem Lett. 2014. PMID: 25262542

6

Synthesis and SAR of 2',3'-bis-O-substituted N(6), 5'-bis-ureidoadenosine derivatives: implications for prodrug delivery and mechanism of action.

Shelton JR, Cutler CE, Browning MS, Balzarini J, Peterson MA. Shelton JR, et al. Among authors: peterson ma. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6067-71. doi: 10.1016/j.bmcl.2012.08.050. Epub 2012 Aug 21. Bioorg Med Chem Lett. 2012. PMID: 22959517

7

Synthesis of amide-linked [(3')CH2CO-NH(5')] nucleoside analogues of small oligonucleotides.

Robins MJ, Doboszewski B, Nilsson BL, Peterson MA. Robins MJ, et al. Among authors: peterson ma. Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):69-86. doi: 10.1080/15257770008032997. Nucleosides Nucleotides Nucleic Acids. 2000. PMID: 10772703

8

Glucose-derived 3'-(carboxymethyl)-3'-deoxyribonucleosides and 2', 3'-lactones as synthetic precursors for amide-linked oligonucleotide analogues.

Robins MJ, Doboszewski B, Timoshchuk VA, Peterson MA. Robins MJ, et al. Among authors: peterson ma. J Org Chem. 2000 May 19;65(10):2939-45. doi: 10.1021/jo991399g. J Org Chem. 2000. PMID: 10814181

9

Amide-Linked Ribonucleoside Dimers Derived from 5'-Amino-5'-deoxy- and 3'-(Carboxymethyl)-3'-deoxynucleoside Precursors(1).

Peterson MA, Nilsson BL, Sarker S, Doboszewski B, Zhang W, Robins MJ. Peterson MA, et al. J Org Chem. 1999 Oct 29;64(22):8183-8192. doi: 10.1021/jo9908647. J Org Chem. 1999. PMID: 11674735

10

Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway.

Balzarini J, Gago F, Kulik W, van Kuilenburg AB, Karlsson A, Peterson MA, Robins MJ. Balzarini J, et al. Among authors: peterson ma. J Biol Chem. 2012 Aug 31;287(36):30444-54. doi: 10.1074/jbc.M112.378091. Epub 2012 Jun 24. J Biol Chem. 2012. PMID: 22730407 Free PMC article.

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