Kulagowski JJ - Search Results

1

1-Phenyl-8-azabicyclo[3.2.1]octane ethers: a novel series of neurokinin (NK1) antagonists.

Huscroft IT, Carlson EJ, Chicchi GG, Kurtz MM, London C, Raubo P, Wheeldon A, Kulagowski JJ. Huscroft IT, et al. Among authors: kulagowski jj. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2008-12. doi: 10.1016/j.bmcl.2005.12.069. Epub 2006 Jan 18. Bioorg Med Chem Lett. 2006. PMID: 16413782

2

Synthesis and structure-activity relationships of 8-azabicyclo[3.2.1]octane benzylamine NK1 antagonists.

Thomson CG, Carlson E, Chicchi GG, Kulagowski JJ, Kurtz MM, Swain CJ, Tsao KL, Wheeldon A. Thomson CG, et al. Among authors: kulagowski jj. Bioorg Med Chem Lett. 2006 Feb 15;16(4):811-4. doi: 10.1016/j.bmcl.2005.11.026. Epub 2005 Nov 22. Bioorg Med Chem Lett. 2006. PMID: 16307878

3

Aminoalkyl phenyl sulfones--a novel series of 5-HT7 receptor ligands.

Raubo P, Beer MS, Hunt PA, Huscroft IT, London C, Stanton JA, Kulagowski JJ. Raubo P, et al. Among authors: kulagowski jj. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1255-8. doi: 10.1016/j.bmcl.2005.11.067. Epub 2005 Dec 7. Bioorg Med Chem Lett. 2006. PMID: 16337790

4

Novel N1-(benzyl)cinnamamidine derived NR2B subtype-selective NMDA receptor antagonists.

Curtis NR, Diggle HJ, Kulagowski JJ, London C, Grimwood S, Hutson PH, Murray F, Richards P, Macaulay A, Wafford KA. Curtis NR, et al. Among authors: kulagowski jj. Bioorg Med Chem Lett. 2003 Feb 24;13(4):693-6. doi: 10.1016/s0960-894x(02)01060-0. Bioorg Med Chem Lett. 2003. PMID: 12639560

5

Thiazoles and thiopyridines: novel series of high affinity h5HT(7) ligands.

Thomson CG, Beer MS, Curtis NR, Diggle HJ, Handford E, Kulagowski JJ. Thomson CG, et al. Among authors: kulagowski jj. Bioorg Med Chem Lett. 2004 Feb 9;14(3):677-80. doi: 10.1016/j.bmcl.2003.11.050. Bioorg Med Chem Lett. 2004. PMID: 14741267

6

Synthesis and sar of 2- and 3-substituted 7-azaindoles as potential dopamine D4 ligands.

Curtis NR, Kulagowski JJ, Leeson PD, Ridgill MP, Emms F, Freedman SB, Patel S, Patel S. Curtis NR, et al. Among authors: kulagowski jj. Bioorg Med Chem Lett. 1999 Feb 22;9(4):585-8. doi: 10.1016/s0960-894x(99)00025-6. Bioorg Med Chem Lett. 1999. PMID: 10098669

7

Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression.

Guscott M, Bristow LJ, Hadingham K, Rosahl TW, Beer MS, Stanton JA, Bromidge F, Owens AP, Huscroft I, Myers J, Rupniak NM, Patel S, Whiting PJ, Hutson PH, Fone KC, Biello SM, Kulagowski JJ, McAllister G. Guscott M, et al. Among authors: kulagowski jj. Neuropharmacology. 2005 Mar;48(4):492-502. doi: 10.1016/j.neuropharm.2004.11.015. Neuropharmacology. 2005. PMID: 15755477

8

Orally efficacious NR2B-selective NMDA receptor antagonists.

Claiborne CF, McCauley JA, Libby BE, Curtis NR, Diggle HJ, Kulagowski JJ, Michelson SR, Anderson KD, Claremon DA, Freidinger RM, Bednar RA, Mosser SD, Gaul SL, Connolly TM, Condra CL, Bednar B, Stump GL, Lynch JJ, Macaulay A, Wafford KA, Koblan KS, Liverton NJ. Claiborne CF, et al. Among authors: kulagowski jj. Bioorg Med Chem Lett. 2003 Feb 24;13(4):697-700. doi: 10.1016/s0960-894x(02)01061-2. Bioorg Med Chem Lett. 2003. PMID: 12639561

9

3'-(Arylmethyl)- and 3'-(aryloxy)-3-phenyl-4-hydroxyquinolin-2(1H)-ones: orally active antagonists of the glycine site on the NMDA receptor.

Kulagowski JJ, Baker R, Curtis NR, Leeson PD, Mawer IM, Moseley AM, Ridgill MP, Rowley M, Stansfield I, Foster AC, et al. Kulagowski JJ, et al. J Med Chem. 1994 May 13;37(10):1402-5. doi: 10.1021/jm00036a002. J Med Chem. 1994. PMID: 8182696 No abstract available.

10

Effect of plasma protein binding on in vivo activity and brain penetration of glycine/NMDA receptor antagonists.

Rowley M, Kulagowski JJ, Watt AP, Rathbone D, Stevenson GI, Carling RW, Baker R, Marshall GR, Kemp JA, Foster AC, Grimwood S, Hargreaves R, Hurley C, Saywell KL, Tricklebank MD, Leeson PD. Rowley M, et al. Among authors: kulagowski jj. J Med Chem. 1997 Dec 5;40(25):4053-68. doi: 10.1021/jm970417o. J Med Chem. 1997. PMID: 9406596

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