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Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole.
Yates MS, Kwak MK, Egner PA, Groopman JD, Bodreddigari S, Sutter TR, Baumgartner KJ, Roebuck BD, Liby KT, Yore MM, Honda T, Gribble GW, Sporn MB, Kensler TW. Yates MS, et al. Among authors: kensler tw. Cancer Res. 2006 Feb 15;66(4):2488-94. doi: 10.1158/0008-5472.CAN-05-3823. Cancer Res. 2006. PMID: 16489057
Keap1 eye on the target: chemoprevention of liver cancer.
Yates MS, Kensler TW. Yates MS, et al. Among authors: kensler tw. Acta Pharmacol Sin. 2007 Sep;28(9):1331-42. doi: 10.1111/j.1745-7254.2007.00688.x. Acta Pharmacol Sin. 2007. PMID: 17723167 Review.
Chemopreventive promise of targeting the Nrf2 pathway.
Yates MS, Kensler TW. Yates MS, et al. Among authors: kensler tw. Drug News Perspect. 2007 Mar;20(2):109-17. doi: 10.1358/dnp.2007.20.2.108343. Drug News Perspect. 2007. PMID: 17440634 Free article. Review.
Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils.
Thimmulappa RK, Fuchs RJ, Malhotra D, Scollick C, Traore K, Bream JH, Trush MA, Liby KT, Sporn MB, Kensler TW, Biswal S. Thimmulappa RK, et al. Among authors: kensler tw. Antioxid Redox Signal. 2007 Nov;9(11):1963-70. doi: 10.1089/ars.2007.1745. Antioxid Redox Signal. 2007. PMID: 17822364 Free PMC article.
389 results