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Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole.
Yates MS, Kwak MK, Egner PA, Groopman JD, Bodreddigari S, Sutter TR, Baumgartner KJ, Roebuck BD, Liby KT, Yore MM, Honda T, Gribble GW, Sporn MB, Kensler TW. Yates MS, et al. Among authors: sutter tr. Cancer Res. 2006 Feb 15;66(4):2488-94. doi: 10.1158/0008-5472.CAN-05-3823. Cancer Res. 2006. PMID: 16489057
Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.
Yates MS, Tran QT, Dolan PM, Osburn WO, Shin S, McCulloch CC, Silkworth JB, Taguchi K, Yamamoto M, Williams CR, Liby KT, Sporn MB, Sutter TR, Kensler TW. Yates MS, et al. Among authors: sutter tr. Carcinogenesis. 2009 Jun;30(6):1024-31. doi: 10.1093/carcin/bgp100. Epub 2009 Apr 21. Carcinogenesis. 2009. PMID: 19386581 Free PMC article.
Complete protection against aflatoxin B(1)-induced liver cancer with a triterpenoid: DNA adduct dosimetry, molecular signature, and genotoxicity threshold.
Johnson NM, Egner PA, Baxter VK, Sporn MB, Wible RS, Sutter TR, Groopman JD, Kensler TW, Roebuck BD. Johnson NM, et al. Among authors: sutter tr. Cancer Prev Res (Phila). 2014 Jul;7(7):658-65. doi: 10.1158/1940-6207.CAPR-13-0430. Epub 2014 Mar 24. Cancer Prev Res (Phila). 2014. PMID: 24662598 Free PMC article.
Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat.
Roebuck BD, Johnson DN, Sutter CH, Egner PA, Scholl PF, Friesen MD, Baumgartner KJ, Ware NM, Bodreddigari S, Groopman JD, Kensler TW, Sutter TR. Roebuck BD, et al. Among authors: sutter tr, sutter ch. Toxicol Sci. 2009 May;109(1):41-9. doi: 10.1093/toxsci/kfp003. Epub 2009 Jan 23. Toxicol Sci. 2009. PMID: 19168568 Free PMC article.
114 results