Wilhelm SM - Search Results

1

BAY 43-9006 inhibition of oncogenic RET mutants.

Carlomagno F, Anaganti S, Guida T, Salvatore G, Troncone G, Wilhelm SM, Santoro M. Carlomagno F, et al. Among authors: wilhelm sm. J Natl Cancer Inst. 2006 Mar 1;98(5):326-34. doi: 10.1093/jnci/djj069. J Natl Cancer Inst. 2006. PMID: 16507829

2

BRAF is a therapeutic target in aggressive thyroid carcinoma.

Salvatore G, De Falco V, Salerno P, Nappi TC, Pepe S, Troncone G, Carlomagno F, Melillo RM, Wilhelm SM, Santoro M. Salvatore G, et al. Among authors: wilhelm sm. Clin Cancer Res. 2006 Mar 1;12(5):1623-9. doi: 10.1158/1078-0432.CCR-05-2378. Clin Cancer Res. 2006. PMID: 16533790 Free article.

3

Sorafenib inhibits imatinib-resistant KIT and platelet-derived growth factor receptor beta gatekeeper mutants.

Guida T, Anaganti S, Provitera L, Gedrich R, Sullivan E, Wilhelm SM, Santoro M, Carlomagno F. Guida T, et al. Among authors: wilhelm sm. Clin Cancer Res. 2007 Jun 1;13(11):3363-9. doi: 10.1158/1078-0432.CCR-06-2667. Clin Cancer Res. 2007. PMID: 17545544

4

Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity.

Wilhelm SM, Dumas J, Adnane L, Lynch M, Carter CA, Schütz G, Thierauch KH, Zopf D. Wilhelm SM, et al. Int J Cancer. 2011 Jul 1;129(1):245-55. doi: 10.1002/ijc.25864. Epub 2011 Apr 22. Int J Cancer. 2011. PMID: 21170960 Free article.

5

BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis.

Wilhelm SM, Carter C, Tang L, Wilkie D, McNabola A, Rong H, Chen C, Zhang X, Vincent P, McHugh M, Cao Y, Shujath J, Gawlak S, Eveleigh D, Rowley B, Liu L, Adnane L, Lynch M, Auclair D, Taylor I, Gedrich R, Voznesensky A, Riedl B, Post LE, Bollag G, Trail PA. Wilhelm SM, et al. Cancer Res. 2004 Oct 1;64(19):7099-109. doi: 10.1158/0008-5472.CAN-04-1443. Cancer Res. 2004. PMID: 15466206

6

Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5.

Liu L, Cao Y, Chen C, Zhang X, McNabola A, Wilkie D, Wilhelm S, Lynch M, Carter C. Liu L, et al. Cancer Res. 2006 Dec 15;66(24):11851-8. doi: 10.1158/0008-5472.CAN-06-1377. Cancer Res. 2006. PMID: 17178882

7

BAY 43-9006: preclinical data.

Wilhelm S, Chien DS. Wilhelm S, et al. Curr Pharm Des. 2002;8(25):2255-7. doi: 10.2174/1381612023393026. Curr Pharm Des. 2002. PMID: 12369853 Review.

8

Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models.

Chang YS, Adnane J, Trail PA, Levy J, Henderson A, Xue D, Bortolon E, Ichetovkin M, Chen C, McNabola A, Wilkie D, Carter CA, Taylor IC, Lynch M, Wilhelm S. Chang YS, et al. Cancer Chemother Pharmacol. 2007 Apr;59(5):561-74. doi: 10.1007/s00280-006-0393-4. Epub 2006 Dec 8. Cancer Chemother Pharmacol. 2007. PMID: 17160391

9

Regorafenib (BAY 73-4506): antitumor and antimetastatic activities in preclinical models of colorectal cancer.

Schmieder R, Hoffmann J, Becker M, Bhargava A, Müller T, Kahmann N, Ellinghaus P, Adams R, Rosenthal A, Thierauch KH, Scholz A, Wilhelm SM, Zopf D. Schmieder R, et al. Among authors: wilhelm sm. Int J Cancer. 2014 Sep 15;135(6):1487-96. doi: 10.1002/ijc.28669. Epub 2014 Apr 17. Int J Cancer. 2014. PMID: 24347491 Free PMC article.

10

Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature.

Adnane L, Trail PA, Taylor I, Wilhelm SM. Adnane L, et al. Among authors: wilhelm sm. Methods Enzymol. 2006;407:597-612. doi: 10.1016/S0076-6879(05)07047-3. Methods Enzymol. 2006. PMID: 16757355

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