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Mechanisms of Action of the KCa2-Negative Modulator AP30663, a Novel Compound in Development for Treatment of Atrial Fibrillation in Man.
Bentzen BH, Bomholtz SH, Simó-Vicens R, Folkersen L, Abildgaard L, Speerschneider T, Muthukumarasamy KM, Edvardsson N, Sørensen US, Grunnet M, Diness JG. Bentzen BH, et al. Among authors: abildgaard l. Front Pharmacol. 2020 May 6;11:610. doi: 10.3389/fphar.2020.00610. eCollection 2020. Front Pharmacol. 2020. PMID: 32477117 Free PMC article.
The KCa2 Channel Inhibitor AP30663 Selectively Increases Atrial Refractoriness, Converts Vernakalant-Resistant Atrial Fibrillation and Prevents Its Reinduction in Conscious Pigs.
Diness JG, Kirchhoff JE, Speerschneider T, Abildgaard L, Edvardsson N, Sørensen US, Grunnet M, Bentzen BH. Diness JG, et al. Among authors: abildgaard l. Front Pharmacol. 2020 Feb 28;11:159. doi: 10.3389/fphar.2020.00159. eCollection 2020. Front Pharmacol. 2020. PMID: 32180722 Free PMC article.
The KCa2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts.
Kirchhoff JE, Skarsfeldt MA, Muthukumarasamy KM, Simó-Vicens R, Bomholtz SH, Abildgaard L, Jespersen T, Sørensen US, Grunnet M, Bentzen BH, Diness JG. Kirchhoff JE, et al. Among authors: abildgaard l. Front Pharmacol. 2019 Jun 19;10:668. doi: 10.3389/fphar.2019.00668. eCollection 2019. Front Pharmacol. 2019. PMID: 31275147 Free PMC article.
pH-dependent inhibition of K₂P3.1 prolongs atrial refractoriness in whole hearts.
Skarsfeldt MA, Jepps TA, Bomholtz SH, Abildgaard L, Sørensen US, Gregers E, Svendsen JH, Diness JG, Grunnet M, Schmitt N, Olesen SP, Bentzen BH. Skarsfeldt MA, et al. Among authors: abildgaard l. Pflugers Arch. 2016 Apr;468(4):643-54. doi: 10.1007/s00424-015-1779-0. Epub 2016 Jan 5. Pflugers Arch. 2016. PMID: 26729267
18 results