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Apoptosis and aging: role of p66Shc redox protein.
Migliaccio E, Giorgio M, Pelicci PG. Migliaccio E, et al. Among authors: giorgio m. Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):600-8. doi: 10.1089/ars.2006.8.600. Antioxid Redox Signal. 2006. PMID: 16677103 Review.
The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.
Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, Martin-Padura I, Pelliccia G, Trinei M, Bono M, Puri C, Tacchetti C, Ferrini M, Mannucci R, Nicoletti I, Lanfrancone L, Giorgio M, Pelicci PG. Orsini F, et al. Among authors: giorgio m. J Biol Chem. 2004 Jun 11;279(24):25689-95. doi: 10.1074/jbc.M401844200. Epub 2004 Apr 12. J Biol Chem. 2004. PMID: 15078873 Free article.
p66ShcA modulates tissue response to hindlimb ischemia.
Zaccagnini G, Martelli F, Fasanaro P, Magenta A, Gaetano C, Di Carlo A, Biglioli P, Giorgio M, Martin-Padura I, Pelicci PG, Capogrossi MC. Zaccagnini G, et al. Among authors: giorgio m. Circulation. 2004 Jun 15;109(23):2917-23. doi: 10.1161/01.CIR.0000129309.58874.0F. Epub 2004 Jun 1. Circulation. 2004. PMID: 15173034
Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene.
Rota M, LeCapitaine N, Hosoda T, Boni A, De Angelis A, Padin-Iruegas ME, Esposito G, Vitale S, Urbanek K, Casarsa C, Giorgio M, Lüscher TF, Pelicci PG, Anversa P, Leri A, Kajstura J. Rota M, et al. Among authors: giorgio m. Circ Res. 2006 Jul 7;99(1):42-52. doi: 10.1161/01.RES.0000231289.63468.08. Epub 2006 Jun 8. Circ Res. 2006. PMID: 16763167
246 results