Wakabayashi H - Search Results

1

pH-dependent association of factor VIII chains: enhancement of affinity at physiological pH by Cu2+.

Wakabayashi H, Zhou Q, Nogami K, Ansong C, Varfaj F, Miles S, Fay PJ. Wakabayashi H, et al. Biochim Biophys Acta. 2006 Jun;1764(6):1094-101. doi: 10.1016/j.bbapap.2006.04.004. Epub 2006 Apr 22. Biochim Biophys Acta. 2006. PMID: 16731058 Free PMC article.

2

Ca(2+) binding to both the heavy and light chains of factor VIII is required for cofactor activity.

Wakabayashi H, Schmidt KM, Fay PJ. Wakabayashi H, et al. Biochemistry. 2002 Jul 2;41(26):8485-92. doi: 10.1021/bi025589o. Biochemistry. 2002. PMID: 12081499

3

Mn2+ binding to factor VIII subunits and its effect on cofactor activity.

Wakabayashi H, Zhen Z, Schmidt KM, Fay PJ. Wakabayashi H, et al. Biochemistry. 2003 Jan 14;42(1):145-53. doi: 10.1021/bi026430e. Biochemistry. 2003. PMID: 12515549

4

Mechanisms of factor Xa-catalyzed cleavage of the factor VIIIa A1 subunit resulting in cofactor inactivation.

Nogami K, Wakabayashi H, Fay PJ. Nogami K, et al. Among authors: wakabayashi h. J Biol Chem. 2003 May 9;278(19):16502-9. doi: 10.1074/jbc.M213044200. Epub 2003 Feb 26. J Biol Chem. 2003. PMID: 12606556 Free article.

5

Residues 110-126 in the A1 domain of factor VIII contain a Ca2+ binding site required for cofactor activity.

Wakabayashi H, Freas J, Zhou Q, Fay PJ. Wakabayashi H, et al. J Biol Chem. 2004 Mar 26;279(13):12677-84. doi: 10.1074/jbc.M311042200. Epub 2004 Jan 13. J Biol Chem. 2004. PMID: 14722121 Free article.

6

Identification of a factor Xa-interactive site within residues 337-372 of the factor VIII heavy chain.

Nogami K, Lapan KA, Zhou Q, Wakabayashi H, Fay PJ. Nogami K, et al. Among authors: wakabayashi h. J Biol Chem. 2004 Apr 16;279(16):15763-71. doi: 10.1074/jbc.M400568200. Epub 2004 Feb 4. J Biol Chem. 2004. PMID: 14764590 Free article.

We recently demonstrated that the residues 337-372, comprising the acidic C-terminal region in A1 subunit, interact with factor Xa during the proteolytic inactivation of factor VIIIa (Nogami, K., Wakabayashi, H., and Fay, P. J. (2003) J. Biol. Chem. 278, 16502-16509 …

We recently demonstrated that the residues 337-372, comprising the acidic C-terminal region in A1 subunit, interact with factor Xa during th …

7

Mechanisms of interactions of factor X and factor Xa with the acidic region in the factor VIII A1 domain.

Nogami K, Freas J, Manithody C, Wakabayashi H, Rezaie AR, Fay PJ. Nogami K, et al. Among authors: wakabayashi h. J Biol Chem. 2004 Aug 6;279(32):33104-13. doi: 10.1074/jbc.M405537200. Epub 2004 May 27. J Biol Chem. 2004. PMID: 15166225 Free article.

8

Localization of a pH-dependent, A2 subunit-interactive surface within the factor VIIIa A1 subunit.

Nogami K, Wakabayashi H, Ansong C, Fay PJ. Nogami K, et al. Among authors: wakabayashi h. Biochim Biophys Acta. 2004 Sep 1;1701(1-2):25-35. doi: 10.1016/j.bbapap.2004.06.002. Biochim Biophys Acta. 2004. PMID: 15450173

9

Thrombin-catalyzed activation of factor VIII with His substituted for Arg372 at the P1 site.

Nogami K, Zhou Q, Wakabayashi H, Fay PJ. Nogami K, et al. Among authors: wakabayashi h. Blood. 2005 Jun 1;105(11):4362-8. doi: 10.1182/blood-2004-10-3939. Epub 2005 Feb 10. Blood. 2005. PMID: 15705787 Free PMC article.

10

Exosite-interactive regions in the A1 and A2 domains of factor VIII facilitate thrombin-catalyzed cleavage of heavy chain.

Nogami K, Zhou Q, Myles T, Leung LL, Wakabayashi H, Fay PJ. Nogami K, et al. Among authors: wakabayashi h. J Biol Chem. 2005 May 6;280(18):18476-87. doi: 10.1074/jbc.M412778200. Epub 2005 Mar 3. J Biol Chem. 2005. PMID: 15746105 Free article.

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