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Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation.
Menini S, Iacobini C, Ricci C, Oddi G, Pesce C, Pugliese F, Block K, Abboud HE, Giorgio M, Migliaccio E, Pelicci PG, Pugliese G. Menini S, et al. Among authors: migliaccio e. Diabetologia. 2007 Sep;50(9):1997-2007. doi: 10.1007/s00125-007-0728-7. Epub 2007 Jul 5. Diabetologia. 2007. PMID: 17611735
Apoptosis and aging: role of p66Shc redox protein.
Migliaccio E, Giorgio M, Pelicci PG. Migliaccio E, et al. Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):600-8. doi: 10.1089/ars.2006.8.600. Antioxid Redox Signal. 2006. PMID: 16677103 Review.
p66Shc-generated oxidative signal promotes fat accumulation.
Berniakovich I, Trinei M, Stendardo M, Migliaccio E, Minucci S, Bernardi P, Pelicci PG, Giorgio M. Berniakovich I, et al. Among authors: migliaccio e. J Biol Chem. 2008 Dec 5;283(49):34283-93. doi: 10.1074/jbc.M804362200. Epub 2008 Oct 6. J Biol Chem. 2008. PMID: 18838380 Free PMC article.
P66Shc signals to age.
Trinei M, Berniakovich I, Beltrami E, Migliaccio E, Fassina A, Pelicci P, Giorgio M. Trinei M, et al. Among authors: migliaccio e. Aging (Albany NY). 2009 Jun 5;1(6):503-10. doi: 10.18632/aging.100057. Aging (Albany NY). 2009. PMID: 20157533 Free PMC article. Review.
Erratum. Deletion of p66Shc Longevity Gene Protects Against Experimental Diabetic Glomerulopathy by Preventing Diabetes-Induced Oxidative Stress. Diabetes 2006;55:1642-1650.
Menini S, Amadio L, Oddi G, Ricci C, Pesce C, Pugliese F, Giorgio M, Migliaccio E, Pelicci P, Iacobini C, Pugliese G. Menini S, et al. Among authors: migliaccio e. Diabetes. 2018 Jan;67(1):165. doi: 10.2337/db18-er01a. Epub 2017 Oct 24. Diabetes. 2018. PMID: 29066598 Free PMC article. No abstract available.
A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.
Trinei M, Giorgio M, Cicalese A, Barozzi S, Ventura A, Migliaccio E, Milia E, Padura IM, Raker VA, Maccarana M, Petronilli V, Minucci S, Bernardi P, Lanfrancone L, Pelicci PG. Trinei M, et al. Among authors: migliaccio e. Oncogene. 2002 May 30;21(24):3872-8. doi: 10.1038/sj.onc.1205513. Oncogene. 2002. PMID: 12032825
49 results