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Not all Shc's roads lead to Ras.
Bonfini L, Migliaccio E, Pelicci G, Lanfrancone L, Pelicci PG. Bonfini L, et al. Among authors: pelicci pg, pelicci g. Trends Biochem Sci. 1996 Jul;21(7):257-61. Trends Biochem Sci. 1996. PMID: 8755247 Review.
A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.
Trinei M, Giorgio M, Cicalese A, Barozzi S, Ventura A, Migliaccio E, Milia E, Padura IM, Raker VA, Maccarana M, Petronilli V, Minucci S, Bernardi P, Lanfrancone L, Pelicci PG. Trinei M, et al. Among authors: pelicci pg. Oncogene. 2002 May 30;21(24):3872-8. doi: 10.1038/sj.onc.1205513. Oncogene. 2002. PMID: 12032825
Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.
Napoli C, Martin-Padura I, de Nigris F, Giorgio M, Mansueto G, Somma P, Condorelli M, Sica G, De Rosa G, Pelicci P. Napoli C, et al. Among authors: pelicci p. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2112-6. doi: 10.1073/pnas.0336359100. Epub 2003 Feb 5. Proc Natl Acad Sci U S A. 2003. PMID: 12571362 Free PMC article.
p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells.
Pacini S, Pellegrini M, Migliaccio E, Patrussi L, Ulivieri C, Ventura A, Carraro F, Naldini A, Lanfrancone L, Pelicci P, Baldari CT. Pacini S, et al. Among authors: pelicci p. Mol Cell Biol. 2004 Feb;24(4):1747-57. doi: 10.1128/MCB.24.4.1747-1757.2004. Mol Cell Biol. 2004. PMID: 14749389 Free PMC article.
543 results