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Cardiac outcomes after screening for asymptomatic coronary artery disease in patients with type 2 diabetes: the DIAD study: a randomized controlled trial.
Young LH, Wackers FJ, Chyun DA, Davey JA, Barrett EJ, Taillefer R, Heller GV, Iskandrian AE, Wittlin SD, Filipchuk N, Ratner RE, Inzucchi SE; DIAD Investigators. Young LH, et al. JAMA. 2009 Apr 15;301(15):1547-55. doi: 10.1001/jama.2009.476. JAMA. 2009. PMID: 19366774 Free PMC article. Clinical Trial.
Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy.
Creek D, Giannangelo C, Challis M, Siddiqui G, Edgar R, Malcolm T, Webb C, Drinkwater N, Vinh N, MacRaild C, Counihan N, Duffy S, Wittlin S, Devine S, Avery V, de Koning-Ward T, Scammells P, McGowan S. Creek D, et al. Among authors: wittlin s. Res Sq [Preprint]. 2024 Apr 26:rs.3.rs-3251230. doi: 10.21203/rs.3.rs-3251230/v3. Res Sq. 2024. PMID: 38746424 Free PMC article. Preprint.
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity.
Edgar RCS, Malcolm TR, Siddiqui G, Giannangelo C, Counihan NA, Challis M, Duffy S, Chowdhury M, Marfurt J, Dans M, Wirjanata G, Noviyanti R, Daware K, Suraweera CD, Price RN, Wittlin S, Avery VM, Drinkwater N, Charman SA, Creek DJ, de Koning-Ward TF, Scammells PJ, McGowan S. Edgar RCS, et al. Among authors: wittlin s. mBio. 2024 May 8:e0096624. doi: 10.1128/mbio.00966-24. Online ahead of print. mBio. 2024. PMID: 38717141 Free article.
hERG, Plasmodium Life Cycle, and Cross Resistance Profiling of New Azabenzimidazole Analogues of Astemizole.
Mambwe D, Coertzen D, Leshabane M, Mulubwa M, Njoroge M, Gibhard L, Girling G, Wicht KJ, Lee MCS, Wittlin S, Moreira DRM, Birkholtz LM, Chibale K. Mambwe D, et al. Among authors: wittlin s. ACS Med Chem Lett. 2024 Mar 18;15(4):463-469. doi: 10.1021/acsmedchemlett.3c00496. eCollection 2024 Apr 11. ACS Med Chem Lett. 2024. PMID: 38628794 Free PMC article.
Next Generation Chemiluminescent Probes for Antimalarial Drug Discovery.
Hellingman A, Sifoniou K, Buser T, Thommen BT, Walz A, Passecker A, Collins J, Hupfeld M, Wittlin S, Witmer K, Brancucci NMB. Hellingman A, et al. Among authors: wittlin s. ACS Infect Dis. 2024 Apr 12;10(4):1286-1297. doi: 10.1021/acsinfecdis.3c00707. Epub 2024 Apr 1. ACS Infect Dis. 2024. PMID: 38556981 Free PMC article.
Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein.
Nguyen W, Boulet C, Dans MG, Loi K, Jarman KE, Watson GM, Tham WH, Fairhurst KJ, Yeo T, Fidock DA, Wittlin S, Chowdury M, de Koning-Ward TF, Chen G, Yan D, Charman SA, Baud D, Brand S, Jackson PF, Cowman AF, Gilson PR, Sleebs BE. Nguyen W, et al. Among authors: wittlin s. Eur J Med Chem. 2024 Apr 15;270:116354. doi: 10.1016/j.ejmech.2024.116354. Epub 2024 Mar 25. Eur J Med Chem. 2024. PMID: 38554474 Free article.
209 results