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Pharmacologic blockade of angiopoietin-2 is efficacious against model hemangiomas in mice.
Perry BN, Govindarajan B, Bhandarkar SS, Knaus UG, Valo M, Sturk C, Carrillo CO, Sohn A, Cerimele F, Dumont D, Losken A, Williams J, Brown LF, Tan X, Ioffe E, Yancopoulos GD, Arbiser JL. Perry BN, et al. Among authors: ioffe e. J Invest Dermatol. 2006 Oct;126(10):2316-22. doi: 10.1038/sj.jid.5700413. Epub 2006 Jun 1. J Invest Dermatol. 2006. PMID: 16741507 Free article.
Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells.
Daly C, Pasnikowski E, Burova E, Wong V, Aldrich TH, Griffiths J, Ioffe E, Daly TJ, Fandl JP, Papadopoulos N, McDonald DM, Thurston G, Yancopoulos GD, Rudge JS. Daly C, et al. Among authors: ioffe e. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15491-6. doi: 10.1073/pnas.0607538103. Epub 2006 Oct 9. Proc Natl Acad Sci U S A. 2006. PMID: 17030814 Free PMC article.
The anti-inflammatory actions of angiopoietin-1.
Thurston G, Rudge JS, Ioffe E, Papadopoulos N, Daly C, Vuthoori S, Daly T, Wiegand SJ, Yancopoulos GD. Thurston G, et al. Among authors: ioffe e. EXS. 2005;(94):233-45. doi: 10.1007/3-7643-7311-3_16. EXS. 2005. PMID: 15617482 Review. No abstract available.
Suppression of diabetic retinopathy with angiopoietin-1.
Joussen AM, Poulaki V, Tsujikawa A, Qin W, Qaum T, Xu Q, Moromizato Y, Bursell SE, Wiegand SJ, Rudge J, Ioffe E, Yancopoulos GD, Adamis AP. Joussen AM, et al. Among authors: ioffe e. Am J Pathol. 2002 May;160(5):1683-93. doi: 10.1016/S0002-9440(10)61115-7. Am J Pathol. 2002. PMID: 12000720 Free PMC article.
Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering.
Davis S, Papadopoulos N, Aldrich TH, Maisonpierre PC, Huang T, Kovac L, Xu A, Leidich R, Radziejewska E, Rafique A, Goldberg J, Jain V, Bailey K, Karow M, Fandl J, Samuelsson SJ, Ioffe E, Rudge JS, Daly TJ, Radziejewski C, Yancopoulos GD. Davis S, et al. Among authors: ioffe e. Nat Struct Biol. 2003 Jan;10(1):38-44. doi: 10.1038/nsb880. Nat Struct Biol. 2003. PMID: 12469114
40 results