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Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction.
Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Zhao W, Thiyagarajan M, MacGrogan D, Rodgers JT, Puigserver P, Sadoshima J, Deng H, Pedrini S, Gandy S, Sauve AA, Pasinetti GM. Qin W, et al. Among authors: zhao z, zhao w. J Biol Chem. 2006 Aug 4;281(31):21745-21754. doi: 10.1074/jbc.M602909200. Epub 2006 Jun 2. J Biol Chem. 2006. PMID: 16751189 Free article.
Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity.
Ono K, Condron MM, Ho L, Wang J, Zhao W, Pasinetti GM, Teplow DB. Ono K, et al. Among authors: zhao w. J Biol Chem. 2008 Nov 21;283(47):32176-87. doi: 10.1074/jbc.M806154200. Epub 2008 Sep 24. J Biol Chem. 2008. PMID: 18815129 Free PMC article.
These studies showed that a commercially available grape seed polyphenolic extract, MegaNatural-AZ (MN), significantly attenuated AD-type cognitive deterioration and reduced cerebral amyloid deposition (Wang, J., Ho, L., Zhao, W., Ono, K., Rosensweig, C., Chen, L., …
These studies showed that a commercially available grape seed polyphenolic extract, MegaNatural-AZ (MN), significantly attenuated AD-type co …
Carvedilol as a potential novel agent for the treatment of Alzheimer's disease.
Wang J, Ono K, Dickstein DL, Arrieta-Cruz I, Zhao W, Qian X, Lamparello A, Subnani R, Ferruzzi M, Pavlides C, Ho L, Hof PR, Teplow DB, Pasinetti GM. Wang J, et al. Among authors: zhao w. Neurobiol Aging. 2011 Dec;32(12):2321.e1-12. doi: 10.1016/j.neurobiolaging.2010.05.004. Epub 2010 Jul 1. Neurobiol Aging. 2011. PMID: 20579773 Free PMC article.
Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models.
Gong B, Pan Y, Vempati P, Zhao W, Knable L, Ho L, Wang J, Sastre M, Ono K, Sauve AA, Pasinetti GM. Gong B, et al. Among authors: zhao w. Neurobiol Aging. 2013 Jun;34(6):1581-8. doi: 10.1016/j.neurobiolaging.2012.12.005. Epub 2013 Jan 9. Neurobiol Aging. 2013. PMID: 23312803 Free PMC article.
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