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Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17.
Baker M, Mackenzie IR, Pickering-Brown SM, Gass J, Rademakers R, Lindholm C, Snowden J, Adamson J, Sadovnick AD, Rollinson S, Cannon A, Dwosh E, Neary D, Melquist S, Richardson A, Dickson D, Berger Z, Eriksen J, Robinson T, Zehr C, Dickey CA, Crook R, McGowan E, Mann D, Boeve B, Feldman H, Hutton M. Baker M, et al. Among authors: zehr c. Nature. 2006 Aug 24;442(7105):916-9. doi: 10.1038/nature05016. Epub 2006 Jul 16. Nature. 2006. PMID: 16862116
Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.
Dickey CA, Yue M, Lin WL, Dickson DW, Dunmore JH, Lee WC, Zehr C, West G, Cao S, Clark AM, Caldwell GA, Caldwell KA, Eckman C, Patterson C, Hutton M, Petrucelli L. Dickey CA, et al. Among authors: zehr c. J Neurosci. 2006 Jun 28;26(26):6985-96. doi: 10.1523/JNEUROSCI.0746-06.2006. J Neurosci. 2006. PMID: 16807328 Free PMC article.
Biologic models of neurodegenerative disorders.
Eriksen JL, Zehr C, Lewis J. Eriksen JL, et al. Among authors: zehr c. Handb Clin Neurol. 2008;89:173-88. doi: 10.1016/S0072-9752(07)01216-X. Handb Clin Neurol. 2008. PMID: 18631742 No abstract available.
An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice.
Le Corre S, Klafki HW, Plesnila N, Hübinger G, Obermeier A, Sahagún H, Monse B, Seneci P, Lewis J, Eriksen J, Zehr C, Yue M, McGowan E, Dickson DW, Hutton M, Roder HM. Le Corre S, et al. Among authors: zehr c. Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9673-8. doi: 10.1073/pnas.0602913103. Epub 2006 Jun 12. Proc Natl Acad Sci U S A. 2006. PMID: 16769887 Free PMC article.
Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1.
Duff K, Eckman C, Zehr C, Yu X, Prada CM, Perez-tur J, Hutton M, Buee L, Harigaya Y, Yager D, Morgan D, Gordon MN, Holcomb L, Refolo L, Zenk B, Hardy J, Younkin S. Duff K, et al. Among authors: zehr c. Nature. 1996 Oct 24;383(6602):710-3. doi: 10.1038/383710a0. Nature. 1996. PMID: 8878479
19 results