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Targeting lymphatic vessel activation and CCL21 production by vascular endothelial growth factor receptor-3 inhibition has novel immunomodulatory and antiarteriosclerotic effects in cardiac allografts.
Nykänen AI, Sandelin H, Krebs R, Keränen MA, Tuuminen R, Kärpänen T, Wu Y, Pytowski B, Koskinen PK, Ylä-Herttuala S, Alitalo K, Lemström KB. Nykänen AI, et al. Among authors: pytowski b. Circulation. 2010 Mar 30;121(12):1413-22. doi: 10.1161/CIRCULATIONAHA.109.910703. Epub 2010 Mar 15. Circulation. 2010. PMID: 20231530
Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation.
Baluk P, Tammela T, Ator E, Lyubynska N, Achen MG, Hicklin DJ, Jeltsch M, Petrova TV, Pytowski B, Stacker SA, Ylä-Herttuala S, Jackson DG, Alitalo K, McDonald DM. Baluk P, et al. Among authors: pytowski b. J Clin Invest. 2005 Feb;115(2):247-57. doi: 10.1172/JCI22037. J Clin Invest. 2005. PMID: 15668734 Free PMC article.
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation.
Tammela T, Zarkada G, Wallgard E, Murtomäki A, Suchting S, Wirzenius M, Waltari M, Hellström M, Schomber T, Peltonen R, Freitas C, Duarte A, Isoniemi H, Laakkonen P, Christofori G, Ylä-Herttuala S, Shibuya M, Pytowski B, Eichmann A, Betsholtz C, Alitalo K. Tammela T, et al. Among authors: pytowski b. Nature. 2008 Jul 31;454(7204):656-60. doi: 10.1038/nature07083. Epub 2008 Jun 25. Nature. 2008. PMID: 18594512
VEGF-C promotes the development of lymphatics in bone and bone loss.
Hominick D, Silva A, Khurana N, Liu Y, Dechow PC, Feng JQ, Pytowski B, Rutkowski JM, Alitalo K, Dellinger MT. Hominick D, et al. Among authors: pytowski b. Elife. 2018 Apr 5;7:e34323. doi: 10.7554/eLife.34323. Elife. 2018. PMID: 29620526 Free PMC article.
Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis.
Calvo CF, Fontaine RH, Soueid J, Tammela T, Makinen T, Alfaro-Cervello C, Bonnaud F, Miguez A, Benhaim L, Xu Y, Barallobre MJ, Moutkine I, Lyytikkä J, Tatlisumak T, Pytowski B, Zalc B, Richardson W, Kessaris N, Garcia-Verdugo JM, Alitalo K, Eichmann A, Thomas JL. Calvo CF, et al. Among authors: pytowski b. Genes Dev. 2011 Apr 15;25(8):831-44. doi: 10.1101/gad.615311. Genes Dev. 2011. PMID: 21498572 Free PMC article.
62 results