Horton JD - Search Results

1

Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote.

Zhao Z, Tuakli-Wosornu Y, Lagace TA, Kinch L, Grishin NV, Horton JD, Cohen JC, Hobbs HH. Zhao Z, et al. Among authors: horton jd. Am J Hum Genet. 2006 Sep;79(3):514-23. doi: 10.1086/507488. Epub 2006 Jul 18. Am J Hum Genet. 2006. PMID: 16909389 Free PMC article.

2

Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene.

Yang J, Goldstein JL, Hammer RE, Moon YA, Brown MS, Horton JD. Yang J, et al. Among authors: horton jd. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13607-12. doi: 10.1073/pnas.201524598. Proc Natl Acad Sci U S A. 2001. PMID: 11717426 Free PMC article.

3

Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol.

Yu L, Li-Hawkins J, Hammer RE, Berge KE, Horton JD, Cohen JC, Hobbs HH. Yu L, et al. Among authors: horton jd. J Clin Invest. 2002 Sep;110(5):671-80. doi: 10.1172/JCI16001. J Clin Invest. 2002. PMID: 12208868 Free PMC article.

4

Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver.

Park SW, Moon YA, Horton JD. Park SW, et al. Among authors: horton jd. J Biol Chem. 2004 Nov 26;279(48):50630-8. doi: 10.1074/jbc.M410077200. Epub 2004 Sep 22. J Biol Chem. 2004. PMID: 15385538 Free article.

5

Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity.

Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, Grundy SM, Hobbs HH. Browning JD, et al. Among authors: horton jd. Hepatology. 2004 Dec;40(6):1387-95. doi: 10.1002/hep.20466. Hepatology. 2004. PMID: 15565570

6

Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9.

Rashid S, Curtis DE, Garuti R, Anderson NN, Bashmakov Y, Ho YK, Hammer RE, Moon YA, Horton JD. Rashid S, et al. Among authors: horton jd. Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5374-9. doi: 10.1073/pnas.0501652102. Epub 2005 Apr 1. Proc Natl Acad Sci U S A. 2005. PMID: 15805190 Free PMC article.

7

WholePathwayScope: a comprehensive pathway-based analysis tool for high-throughput data.

Yi M, Horton JD, Cohen JC, Hobbs HH, Stephens RM. Yi M, et al. Among authors: horton jd. BMC Bioinformatics. 2006 Jan 19;7:30. doi: 10.1186/1471-2105-7-30. BMC Bioinformatics. 2006. PMID: 16423281 Free PMC article.

8

Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice.

Lagace TA, Curtis DE, Garuti R, McNutt MC, Park SW, Prather HB, Anderson NN, Ho YK, Hammer RE, Horton JD. Lagace TA, et al. Among authors: horton jd. J Clin Invest. 2006 Nov;116(11):2995-3005. doi: 10.1172/JCI29383. J Clin Invest. 2006. PMID: 17080197 Free PMC article.

9

Molecular biology of PCSK9: its role in LDL metabolism.

Horton JD, Cohen JC, Hobbs HH. Horton JD, et al. Trends Biochem Sci. 2007 Feb;32(2):71-7. doi: 10.1016/j.tibs.2006.12.008. Epub 2007 Jan 9. Trends Biochem Sci. 2007. PMID: 17215125 Free PMC article. Review.

10

Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation.

Zhang DW, Lagace TA, Garuti R, Zhao Z, McDonald M, Horton JD, Cohen JC, Hobbs HH. Zhang DW, et al. Among authors: horton jd. J Biol Chem. 2007 Jun 22;282(25):18602-18612. doi: 10.1074/jbc.M702027200. Epub 2007 Apr 23. J Biol Chem. 2007. PMID: 17452316 Free article.

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