Wiltshire S - Search Results

1

Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.

Groves CJ, Zeggini E, Minton J, Frayling TM, Weedon MN, Rayner NW, Hitman GA, Walker M, Wiltshire S, Hattersley AT, McCarthy MI. Groves CJ, et al. Among authors: wiltshire s. Diabetes. 2006 Sep;55(9):2640-4. doi: 10.2337/db06-0355. Diabetes. 2006. PMID: 16936215

2

Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.

Groves CJ, Wiltshire S, Smedley D, Owen KR, Frayling TM, Walker M, Hitman GA, Levy JC, O'Rahilly S, Menzel S, Hattersley AT, McCarthy MI. Groves CJ, et al. Among authors: wiltshire s. Diabetes. 2003 May;52(5):1300-5. doi: 10.2337/diabetes.52.5.1300. Diabetes. 2003. PMID: 12716770

3

Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11.

Frayling TM, Wiltshire S, Hitman GA, Walker M, Levy JC, Sampson M, Groves CJ, Menzel S, McCarthy MI, Hattersley AT. Frayling TM, et al. Among authors: wiltshire s. Diabetes. 2003 Jul;52(7):1857-63. doi: 10.2337/diabetes.52.7.1857. Diabetes. 2003. PMID: 12829657

4

Evidence from a large U.K. family collection that genes influencing age of onset of type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24.

Wiltshire S, Frayling TM, Groves CJ, Levy JC, Hitman GA, Sampson M, Walker M, Menzel S, Hattersley AT, Cardon LR, McCarthy MI. Wiltshire S, et al. Diabetes. 2004 Mar;53(3):855-60. doi: 10.2337/diabetes.53.3.855. Diabetes. 2004. PMID: 14988275

5

Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate.

Groves CJ, Zeggini E, Walker M, Hitman GA, Levy JC, O'Rahilly S, Hattersley AT, McCarthy MI, Wiltshire S. Groves CJ, et al. Among authors: wiltshire s. Diabetes. 2006 Jun;55(6):1884-9. doi: 10.2337/db05-1674. Diabetes. 2006. PMID: 16731858

6

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.

Morris AP, Voight BF, Teslovich TM, Ferreira T, Segrè AV, Steinthorsdottir V, Strawbridge RJ, Khan H, Grallert H, Mahajan A, Prokopenko I, Kang HM, Dina C, Esko T, Fraser RM, Kanoni S, Kumar A, Lagou V, Langenberg C, Luan J, Lindgren CM, Müller-Nurasyid M, Pechlivanis S, Rayner NW, Scott LJ, Wiltshire S, Yengo L, Kinnunen L, Rossin EJ, Raychaudhuri S, Johnson AD, Dimas AS, Loos RJ, Vedantam S, Chen H, Florez JC, Fox C, Liu CT, Rybin D, Couper DJ, Kao WH, Li M, Cornelis MC, Kraft P, Sun Q, van Dam RM, Stringham HM, Chines PS, Fischer K, Fontanillas P, Holmen OL, Hunt SE, Jackson AU, Kong A, Lawrence R, Meyer J, Perry JR, Platou CG, Potter S, Rehnberg E, Robertson N, Sivapalaratnam S, Stančáková A, Stirrups K, Thorleifsson G, Tikkanen E, Wood AR, Almgren P, Atalay M, Benediktsson R, Bonnycastle LL, Burtt N, Carey J, Charpentier G, Crenshaw AT, Doney AS, Dorkhan M, Edkins S, Emilsson V, Eury E, Forsen T, Gertow K, Gigante B, Grant GB, Groves CJ, Guiducci C, Herder C, Hreidarsson AB, Hui J, James A, Jonsson A, Rathmann W, Klopp N, Kravic J, Krjutškov K, Langford C, Leander K, Lindholm E, Lobbens S, Männistö S, Mirza G, Mühleisen TW, Musk B, Parkin M, Rallidis L, Saramies J, Sen… See abstract for full author list ➔ Morris AP, et al. Among authors: wiltshire s. Nat Genet. 2012 Sep;44(9):981-90. doi: 10.1038/ng.2383. Epub 2012 Aug 12. Nat Genet. 2012. PMID: 22885922 Free PMC article.

7

Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism.

Liew CF, Groves CJ, Wiltshire S, Zeggini E, Frayling TM, Owen KR, Walker M, Hitman GA, Levy JC, O'rahilly S, Hattersley AT, Johnston DG, McCarthy MI. Liew CF, et al. Among authors: wiltshire s. Diabetologia. 2004 Dec;47(12):2168-75. doi: 10.1007/s00125-004-1575-4. Epub 2004 Dec 15. Diabetologia. 2004. PMID: 15662557

8

Epistasis between type 2 diabetes susceptibility Loci on chromosomes 1q21-25 and 10q23-26 in northern Europeans.

Wiltshire S, Bell JT, Groves CJ, Dina C, Hattersley AT, Frayling TM, Walker M, Hitman GA, Vaxillaire M, Farrall M, Froguel P, McCarthy MI. Wiltshire S, et al. Ann Hum Genet. 2006 Nov;70(Pt 6):726-37. doi: 10.1111/j.1469-1809.2006.00289.x. Ann Hum Genet. 2006. PMID: 17044847

9

Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome.

Haddad L, Evans JC, Gharani N, Robertson C, Rush K, Wiltshire S, Frayling TM, Wilkin TJ, Demaine A, Millward A, Hattersley AT, Conway G, Cox NJ, Bell GI, Franks S, McCarthy MI. Haddad L, et al. Among authors: wiltshire s. J Clin Endocrinol Metab. 2002 Jun;87(6):2606-10. doi: 10.1210/jcem.87.6.8608. J Clin Endocrinol Metab. 2002. PMID: 12050223

10

High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people.

Florez JC, Wiltshire S, Agapakis CM, Burtt NP, de Bakker PI, Almgren P, Bengtsson Boström K, Tuomi T, Gaudet D, Daly MJ, Hirschhorn JN, McCarthy MI, Altshuler D, Groop L. Florez JC, et al. Among authors: wiltshire s. Diabetes. 2006 Jan;55(1):128-35. Diabetes. 2006. PMID: 16380485

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