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In silico ADMET traffic lights as a tool for the prioritization of HTS hits.
ChemMedChem. 2006 Nov;1(11):1229-36. doi: 10.1002/cmdc.200600168.
ChemMedChem. 2006.
PMID: 16991174
Improving the hit-to-lead process: data-driven assessment of drug-like and lead-like screening hits.
Wunberg T, Hendrix M, Hillisch A, Lobell M, Meier H, Schmeck C, Wild H, Hinzen B.
Wunberg T, et al. Among authors: hinzen b.
Drug Discov Today. 2006 Feb;11(3-4):175-80. doi: 10.1016/S1359-6446(05)03700-1.
Drug Discov Today. 2006.
PMID: 16533716
Review.
Item in Clipboard
Medicinal chemistry optimization of acyldepsipeptides of the enopeptin class antibiotics.
Hinzen B, Raddatz S, Paulsen H, Lampe T, Schumacher A, Häbich D, Hellwig V, Benet-Buchholz J, Endermann R, Labischinski H, Brötz-Oesterhelt H.
Hinzen B, et al.
ChemMedChem. 2006 Jul;1(7):689-93. doi: 10.1002/cmdc.200600055.
ChemMedChem. 2006.
PMID: 16902918
No abstract available.
Item in Clipboard
Dysregulation of bacterial proteolytic machinery by a new class of antibiotics.
Brötz-Oesterhelt H, Beyer D, Kroll HP, Endermann R, Ladel C, Schroeder W, Hinzen B, Raddatz S, Paulsen H, Henninger K, Bandow JE, Sahl HG, Labischinski H.
Brötz-Oesterhelt H, et al. Among authors: hinzen b.
Nat Med. 2005 Oct;11(10):1082-7. doi: 10.1038/nm1306. Epub 2005 Oct 2.
Nat Med. 2005.
PMID: 16200071
Item in Clipboard
Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease.
Famulla K, Sass P, Malik I, Akopian T, Kandror O, Alber M, Hinzen B, Ruebsamen-Schaeff H, Kalscheuer R, Goldberg AL, Brötz-Oesterhelt H.
Famulla K, et al. Among authors: hinzen b.
Mol Microbiol. 2016 Jul;101(2):194-209. doi: 10.1111/mmi.13362. Epub 2016 Apr 1.
Mol Microbiol. 2016.
PMID: 26919556
Free PMC article.
Item in Clipboard
Antibacterial natural products in medicinal chemistry--exodus or revival?
von Nussbaum F, Brands M, Hinzen B, Weigand S, Häbich D.
von Nussbaum F, et al. Among authors: hinzen b.
Angew Chem Int Ed Engl. 2006 Aug 4;45(31):5072-129. doi: 10.1002/anie.200600350.
Angew Chem Int Ed Engl. 2006.
PMID: 16881035
Review.
Item in Clipboard
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