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Basic mechanisms responsible for osteolytic and osteoblastic bone metastases.
Clin Cancer Res. 2006 Oct 15;12(20 Pt 2):6213s-6216s. doi: 10.1158/1078-0432.CCR-06-1007.
Clin Cancer Res. 2006.
PMID: 17062703
Review.
Pharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone.
Mohammad KS, Chen CG, Balooch G, Stebbins E, McKenna CR, Davis H, Niewolna M, Peng XH, Nguyen DH, Ionova-Martin SS, Bracey JW, Hogue WR, Wong DH, Ritchie RO, Suva LJ, Derynck R, Guise TA, Alliston T.
Mohammad KS, et al.
PLoS One. 2009;4(4):e5275. doi: 10.1371/journal.pone.0005275. Epub 2008 Apr 16.
PLoS One. 2009.
PMID: 19357790
Free PMC article.
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Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation.
Nguyen AN, Stebbins EG, Henson M, O'Young G, Choi SJ, Quon D, Damm D, Reddy M, Ma JY, Haghnazari E, Kapoun AM, Medicherla S, Protter A, Schreiner GF, Kurihara N, Anderson J, Roodman GD, Navas TA, Higgins LS.
Nguyen AN, et al. Among authors: stebbins eg.
Exp Cell Res. 2006 Jun 10;312(10):1909-23. doi: 10.1016/j.yexcr.2006.02.026. Epub 2006 Apr 4.
Exp Cell Res. 2006.
PMID: 16600214
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Inhibition of p38alpha MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-X(L), Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo.
Navas TA, Nguyen AN, Hideshima T, Reddy M, Ma JY, Haghnazari E, Henson M, Stebbins EG, Kerr I, O'Young G, Kapoun AM, Chakravarty S, Mavunkel B, Perumattam J, Luedtke G, Dugar S, Medicherla S, Protter AA, Schreiner GF, Anderson KC, Higgins LS.
Navas TA, et al. Among authors: stebbins eg.
Leukemia. 2006 Jun;20(6):1017-27. doi: 10.1038/sj.leu.2404200.
Leukemia. 2006.
PMID: 16617327
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A selective p38 alpha mitogen-activated protein kinase inhibitor reverses cartilage and bone destruction in mice with collagen-induced arthritis.
Medicherla S, Ma JY, Mangadu R, Jiang Y, Zhao JJ, Almirez R, Kerr I, Stebbins EG, O'Young G, Kapoun AM, Luedtke G, Chakravarty S, Dugar S, Genant HK, Protter AA.
Medicherla S, et al. Among authors: stebbins eg.
J Pharmacol Exp Ther. 2006 Jul;318(1):132-41. doi: 10.1124/jpet.105.098020. Epub 2006 Apr 5.
J Pharmacol Exp Ther. 2006.
PMID: 16597712
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The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins.
Dell EJ, Connor J, Chen S, Stebbins EG, Skiba NP, Mochly-Rosen D, Hamm HE.
Dell EJ, et al. Among authors: stebbins eg.
J Biol Chem. 2002 Dec 20;277(51):49888-95. doi: 10.1074/jbc.M202755200. Epub 2002 Sep 30.
J Biol Chem. 2002.
PMID: 12359736
Free article.
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Binding specificity for RACK1 resides in the V5 region of beta II protein kinase C.
Stebbins EG, Mochly-Rosen D.
Stebbins EG, et al.
J Biol Chem. 2001 Aug 10;276(32):29644-50. doi: 10.1074/jbc.M101044200. Epub 2001 May 31.
J Biol Chem. 2001.
PMID: 11387319
Free article.
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