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Cell-free assays for gamma-secretase activity.
McLendon C, Xin T, Ziani-Cherif C, Murphy MP, Findlay KA, Lewis PA, Pinnix I, Sambamurti K, Wang R, Fauq A, Golde TE. McLendon C, et al. Among authors: golde te. FASEB J. 2000 Dec;14(15):2383-6. doi: 10.1096/fj.00-0286fje. FASEB J. 2000. PMID: 11024004
The presenilin 1 C92S mutation increases abeta 42 production.
Lewis PA, Perez-Tur J, Golde TE, Hardy J. Lewis PA, et al. Among authors: golde te. Biochem Biophys Res Commun. 2000 Oct 14;277(1):261-3. doi: 10.1006/bbrc.2000.3646. Biochem Biophys Res Commun. 2000. PMID: 11027672
Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS-1 mutations that lead to exceptionally high amyloid-beta concentrations.
Houlden H, Baker M, McGowan E, Lewis P, Hutton M, Crook R, Wood NW, Kumar-Singh S, Geddes J, Swash M, Scaravilli F, Holton JL, Lashley T, Tomita T, Hashimoto T, Verkkoniemi A, Kalimo H, Somer M, Paetau A, Martin JJ, Van Broeckhoven C, Golde T, Hardy J, Haltia M, Revesz T. Houlden H, et al. Ann Neurol. 2000 Nov;48(5):806-8. Ann Neurol. 2000. PMID: 11079548
Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin.
Haugabook SJ, Le T, Yager D, Zenk B, Healy BM, Eckman EA, Prada C, Younkin L, Murphy P, Pinnix I, Onstead L, Sambamurti K, Golde TE, Dickson D, Younkin SG, Eckman CB. Haugabook SJ, et al. Among authors: golde te. FASEB J. 2001 Jan;15(1):16-18. doi: 10.1096/fj.00-0528fje. Epub 2000 Nov 9. FASEB J. 2001. PMID: 11099491
337 results