Sierks MR - Search Results

1

Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models.

Levites Y, Smithson LA, Price RW, Dakin RS, Yuan B, Sierks MR, Kim J, McGowan E, Reed DK, Rosenberry TL, Das P, Golde TE. Levites Y, et al. Among authors: sierks mr. FASEB J. 2006 Dec;20(14):2576-8. doi: 10.1096/fj.06-6463fje. Epub 2006 Oct 26. FASEB J. 2006. PMID: 17068112

2

Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity.

Liu R, Yuan B, Emadi S, Zameer A, Schulz P, McAllister C, Lyubchenko Y, Goud G, Sierks MR. Liu R, et al. Among authors: sierks mr. Biochemistry. 2004 Jun 8;43(22):6959-67. doi: 10.1021/bi049933o. Biochemistry. 2004. PMID: 15170333

3

Intracellular targeting and clearance of oligomeric alpha-synuclein alleviates toxicity in mammalian cells.

Yuan B, Sierks MR. Yuan B, et al. Among authors: sierks mr. Neurosci Lett. 2009 Jul 31;459(1):16-8. doi: 10.1016/j.neulet.2009.04.046. Epub 2009 Apr 24. Neurosci Lett. 2009. PMID: 19394405

4

Inhibiting β-secretase activity in Alzheimer's disease cell models with single-chain antibodies specifically targeting APP.

Boddapati S, Levites Y, Sierks MR. Boddapati S, et al. Among authors: sierks mr. J Mol Biol. 2011 Jan 14;405(2):436-47. doi: 10.1016/j.jmb.2010.10.054. Epub 2010 Nov 10. J Mol Biol. 2011. PMID: 21073877

5

Bispecific tandem single chain antibody simultaneously inhibits β-secretase and promotes α-secretase processing of AβPP.

Boddapati S, Levites Y, Suryadi V, Kasturirangan S, Sierks MR. Boddapati S, et al. Among authors: sierks mr. J Alzheimers Dis. 2012;28(4):961-9. doi: 10.3233/JAD-2011-111196. J Alzheimers Dis. 2012. PMID: 22156046

6

Blood-Based Oligomeric and Other Protein Variant Biomarkers to Facilitate Pre-Symptomatic Diagnosis and Staging of Alzheimer's Disease.

Williams SM, Schulz P, Rosenberry TL, Caselli RJ, Sierks MR. Williams SM, et al. Among authors: sierks mr. J Alzheimers Dis. 2017;58(1):23-35. doi: 10.3233/JAD-161116. J Alzheimers Dis. 2017. PMID: 28372328

7

Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia.

Trudler D, Nazor KL, Eisele YS, Grabauskas T, Dolatabadi N, Parker J, Sultan A, Zhong Z, Goodwin MS, Levites Y, Golde TE, Kelly JW, Sierks MR, Schork NJ, Karin M, Ambasudhan R, Lipton SA. Trudler D, et al. Among authors: sierks mr. Proc Natl Acad Sci U S A. 2021 Apr 13;118(15):e2025847118. doi: 10.1073/pnas.2025847118. Proc Natl Acad Sci U S A. 2021. PMID: 33833060 Free PMC article.

8

Single-molecule selection and recovery of structure-specific antibodies using atomic force microscopy.

Shlyakhtenko LS, Yuan B, Emadi S, Lyubchenko YL, Sierks MR. Shlyakhtenko LS, et al. Among authors: sierks mr. Nanomedicine. 2007 Sep;3(3):192-7. doi: 10.1016/j.nano.2007.06.001. Epub 2007 Jul 27. Nanomedicine. 2007. PMID: 17662669

9

Anti-oligomeric Abeta single-chain variable domain antibody blocks Abeta-induced toxicity against human neuroblastoma cells.

Zameer A, Kasturirangan S, Emadi S, Nimmagadda SV, Sierks MR. Zameer A, et al. Among authors: sierks mr. J Mol Biol. 2008 Dec 26;384(4):917-28. doi: 10.1016/j.jmb.2008.09.068. Epub 2008 Oct 7. J Mol Biol. 2008. PMID: 18929576

10

Inhibiting aggregation of alpha-synuclein with human single chain antibody fragments.

Emadi S, Liu R, Yuan B, Schulz P, McAllister C, Lyubchenko Y, Messer A, Sierks MR. Emadi S, et al. Among authors: sierks mr. Biochemistry. 2004 Mar 16;43(10):2871-8. doi: 10.1021/bi036281f. Biochemistry. 2004. PMID: 15005622

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