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Repression of p53 activity by Smyd2-mediated methylation.
Huang J, Perez-Burgos L, Placek BJ, Sengupta R, Richter M, Dorsey JA, Kubicek S, Opravil S, Jenuwein T, Berger SL. Huang J, et al. Among authors: dorsey ja. Nature. 2006 Nov 30;444(7119):629-32. doi: 10.1038/nature05287. Epub 2006 Nov 15. Nature. 2006. PMID: 17108971
G9a and Glp methylate lysine 373 in the tumor suppressor p53.
Huang J, Dorsey J, Chuikov S, Zhang X, Jenuwein T, Reinberg D, Berger SL. Huang J, et al. J Biol Chem. 2010 Mar 26;285(13):9636-9641. doi: 10.1074/jbc.M109.062588. Epub 2010 Jan 29. J Biol Chem. 2010. PMID: 20118233 Free PMC article.
p53 is regulated by the lysine demethylase LSD1.
Huang J, Sengupta R, Espejo AB, Lee MG, Dorsey JA, Richter M, Opravil S, Shiekhattar R, Bedford MT, Jenuwein T, Berger SL. Huang J, et al. Among authors: dorsey ja. Nature. 2007 Sep 6;449(7158):105-8. doi: 10.1038/nature06092. Nature. 2007. PMID: 17805299
Histone H4 lysine 16 acetylation regulates cellular lifespan.
Dang W, Steffen KK, Perry R, Dorsey JA, Johnson FB, Shilatifard A, Kaeberlein M, Kennedy BK, Berger SL. Dang W, et al. Among authors: dorsey ja. Nature. 2009 Jun 11;459(7248):802-7. doi: 10.1038/nature08085. Nature. 2009. PMID: 19516333 Free PMC article.
H3K36 methylation promotes longevity by enhancing transcriptional fidelity.
Sen P, Dang W, Donahue G, Dai J, Dorsey J, Cao X, Liu W, Cao K, Perry R, Lee JY, Wasko BM, Carr DT, He C, Robison B, Wagner J, Gregory BD, Kaeberlein M, Kennedy BK, Boeke JD, Berger SL. Sen P, et al. Genes Dev. 2015 Jul 1;29(13):1362-76. doi: 10.1101/gad.263707.115. Genes Dev. 2015. PMID: 26159996 Free PMC article.
MLL1 is essential for the senescence-associated secretory phenotype.
Capell BC, Drake AM, Zhu J, Shah PP, Dou Z, Dorsey J, Simola DF, Donahue G, Sammons M, Rai TS, Natale C, Ridky TW, Adams PD, Berger SL. Capell BC, et al. Genes Dev. 2016 Feb 1;30(3):321-36. doi: 10.1101/gad.271882.115. Genes Dev. 2016. PMID: 26833731 Free PMC article.
Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications.
Nathan D, Ingvarsdottir K, Sterner DE, Bylebyl GR, Dokmanovic M, Dorsey JA, Whelan KA, Krsmanovic M, Lane WS, Meluh PB, Johnson ES, Berger SL. Nathan D, et al. Among authors: dorsey ja. Genes Dev. 2006 Apr 15;20(8):966-76. doi: 10.1101/gad.1404206. Epub 2006 Apr 5. Genes Dev. 2006. PMID: 16598039 Free PMC article.
23 results